Synthetic Route of 92248-06-1,Some common heterocyclic compound, 92248-06-1, name is Bis(3-methoxyphenyl)amine, molecular formula is C14H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere,Adding 2,2′-dibromo-9,9′-spirobifluorene (0.7 g, 1.48 mmol),Bis (3-methoxyphenyl) amine (1.01 g, 4.44 mmol),Palladium acetate (18mg, 0.082mmol),Cesium carbonate (1.74g, 5.33mmol)And tri-tert-butylphosphine (0.038mL, 0.15mmol) in toluene(10mL) mixed well in the solution,Heat and stir at 110 C for 20 hours.After cooling to room temperature,The reaction was quenched with a saturated ammonium chloride solution.The aqueous layer was extracted three times with ethyl acetate,Use up the combined organic phasesAnd washed with aqueous sodium chloride.After the organic phase was dried over anhydrous sodium sulfate,The solvent was evaporated to dryness under reduced pressure,The obtained product was further purified by silica gel column chromatography,Petroleum ether / ethyl acetate (10: 1, v / v) was used as the eluent.Get pure product,As a white solid.Yield: 95% (1.08 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bis(3-methoxyphenyl)amine, its application will become more common.
Reference:
Patent; Nanjing Tech University; Hang Xiaochun; Qian Chunyue; Huang Wei; Shen Kang; Qin Tianshi; (57 pag.)CN110790629; (2020); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem