Electric Literature of 454-90-0, The chemical industry reduces the impact on the environment during synthesis 454-90-0, name is 3-(Trifluoromethyl)anisole, I believe this compound will play a more active role in future production and life.
A flame-dried 100 mL Schlenk tube was charged with bis(pinacolato)diboron (350 mg, 1.38 mmol), [Ir(COD)Cl]z (12 mg, 0.018 mmol), sodium methoxide (5 mg, 0.09 mmol), and 4,4′-di-tert-butyl-2,2′-dipyridyl (8 mg, 0.03 mmol). The flask was evacuated, placed under argon, and 3-trifluoromethylanisole (2.5 mL) was added. The flask was restoppered and evacuated (full vacuum, 2 minutes). The flask was sealed under vacuum and maintained at 90 C. (oil bath) for 96 h. Thereafter, the contents were transferred to a round bottom flask with the aid of ethyl acetate and purified by Kugelrohr distillation. The product, a viscous oil, distills at 120 C. 10 p.m. Isolated yield 497 mg (1.65 mmol, 60%). 1H NMR (400 MHz, CDCl3) delta 7.62 (s, 1H); 7.43 (s, 1H); 7.18 (s, 1H); 3.82 (s, 1H); 1.32 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)anisole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; The Regents of the University of California; Tanaka, Masahiro; Zhang, Chao; Shokat, Kevan M.; Burlingame, Alma L.; Hansen, Kirk; Bateman, Raynard L.; DiMagno, Stephen G.; (81 pag.)US2016/168151; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem