Reference of 645-36-3,Some common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of an amine of formula g or h (1.1 -1.5 eq) and triethylamine (1.1 eq) in dichloromethane (0.2 M) is added a solution of an acid chloride of formula XI (1 eq) in dichloromethane (0.2 – 1.0 M) at 0-5 C. The cooling bath is removed and the reaction mixture is allowed to warm to room temperature. After 2h the reaction mixture is partitioned between an organic solvent such ethyl acetate or tert-butyl methyl ether and water. The layers are separated. The aqueous layer is extracted with two portions of organic solvent. The combined organic layers are washed with one portion of saturated ammonium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give an amide intermediate of formula XII or XIII, respectively. The title compound was obtained as white solid in quantitative yield from amino acetaldehyde diethyl acetal and tra/?s-4-chlorocarbonyl-cyclohexanecarboxylic acid methyl ester according to general procedure (III). MS m/e: 302 ([M+H]+)
The synthetic route of 645-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DOLENTE, Cosimo; SCHNIDER, Patrick; WO2011/141396; (2011); A1;,
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