Adding a certain compound to certain chemical reactions, such as: 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60789-54-0, name: ((4-Bromobutoxy)methyl)benzene
2-(4-benzyloxy)butyl-propanedioic acid, diethyl ester 19 To a warm solution of sodium (49.5 g, 2.15 mol) in 1 L abs. ethanol there is added diethyl malonate (325 mL, 2.11 mol). The solution is warmed up to 50 C. and crude bromide 18 (410 g, 1.68 mol) is added over a 30 m period. The mixture warms up to 65 C. and is then heated under reflux for 1 h. Most of the solvent is evaporated and to the residue there is added 1 L toluene and 500 mL water. The layers are separated and the organic layer is washed with 2*750 mL water, then dried and evaporated. The residue is purified by bulb-to-bulb distillation to afford 410 g of 19 (1.273 mol, 76%) with bp 170 C. (0.2 mmHg). This product is used as such in the next step. 1 H-NMR (CCl4): delta 1.0-2.0 (m) and 1.2 (t) (12H), 3.2(t, 1II), 3.4 (t, 2H), 4.0 (q, 4H), 4.3 (s, 2II), 7.2 (s, 5H).
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Reference:
Patent; The Horticulture and Food Research Institute of New Zealand Limited; US5677432; (1997); A;,
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