Electric Literature of 1535-73-5, The chemical industry reduces the impact on the environment during synthesis 1535-73-5, name is 3-Trifluoromethoxyaniline, I believe this compound will play a more active role in future production and life.
To Z>zs-(2-chloroethyl)amme hydrochloride (0.2 g, 1.12 mmol) was added 3-trifloromethoxy aniline (0.3 g, 1.68 mmol). The reaction was heated at 190″C for 5 min in a microwave reactor. The residue was neutralized with saturated sodium bicarbonate solution. Aqueous layer was extracted with EtOAc (3x). The combined organic phase was dried over MgSO4 and concentrated. The residue was purified on 2×1000 micron preparative thin layer chromatography plates eluting with 10percent methanol in dichloromethane to give the title compound. IH NMR (500 MHz, CDCl3) delta 7.2 (m, IH), 6.8 (d, 2H, J = 10.3 Hz), 6.71 (s, IH), 6.68 (d, 2H), 3.18 (m, 4H), 3.04 (m, 4H). LC/MS 247 (M+l); HPLC 2.04 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Trifluoromethoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2007/70173; (2007); A2;,
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