Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-6-methoxynaphthalene
Under argon atmosphere, 2.37 g (0.01 mol) of 2-bromo-6-methoxynaphthalene and 40.578 g of Pd (PPh3)(0.5 mmol) of CuI, 0.095 g (0.5 mmol) of CuI and 30.131 g (0.5 mmol) of PPh. After the addition was completed, the mixture was purged with argon three times,Air was removed from the reaction flask, and then 15 ml of triethylamine, 1.96 ml of trimethylethynylsilane and 30 ml of tetrahydrofuran were added.After the addition was completed, the system was allowed to rise to 78 C for 20 h.The reaction mixture was filtered to remove a large amount of insoluble salts and solids. To the filtrate was added 150 ml of methylene chloride and the mixture was washed three times with 150 ml of 5% diluted hydrochloric acid. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. Ether to do the agent.After the column liquid was swirled to a white solid precipitation stopped rotating when placed at room temperature precipitated a large number of white solid, filtered and dried to give a white solid6-Methoxy-2-naphthylethynyltrimethylsilyl2.50 g, yield 98.4%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China University of Science and Technology; Shen Dong; Liu Haipeng; Zheng Zhigang; (18 pag.)CN106336350; (2017); A;,
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