162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C18H21NO4
Example 2 (Z)-1-(2-bromo-3,4,5-trimethoxyphenyl)-3-((2-methoxy-5-((Z)-3,4,5-trimethoxystyryl)phenyl)amino)prop-2-en-1-one (10y) To a stirred solution of (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)aniline (5d) (100 mg, 0.317 mmol) in ethanol (5 ml) 1-(2-bromo-3,4,5-trimethoxyphenyl)prop-2-yn-1-one (6y) (94.9 mg, 0.317 mmol) was added. The reaction mixture was stirred at a temperature of 27 C. for 4 h and the reaction was monitored by TLC using ethyl acetate/hexane (1:1) as a solvent system. Then water (10 ml) was added to reaction mixture. A yellow colour solid appears which was filtered and washed with ethanol. (yield: 150 mg, 76%); mp: 108-110 C.; 1H NMR (CDCl3, 300 MHz) deltadelta (ppm): 3.94 (s, 3H), 3.91 (s, 3H), 3.90 (s, 3H), 3.87 (s, 3H), 3.84 (s, 3H), 3.70 (s, 6H), 5.64 (d, J=8.30 Hz, 1H), 6.49 (d, J=9.06 Hz, 4H), 6.81 (d, J=8.3 Hz, 1H), 6.87 (s, 1H) 6.97 (d, J=8.3 Hz, 1H), 7.14 (s, 1H), 7.28-7.19 (m, 1H), 11.92 (d, J=12.8 Hz, NH); FABMAS: (M+H)=614.
The synthetic route of 162705-07-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Council of Scientific and Industrial Research; Ahmed, Kamal; Gajjela, Bharath Kumar; Anver, Basha Shaik; Vangala, Santhosh Reddy; Mahesh, Rasala; US2015/322009; (2015); A1;,
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