Some common heterocyclic compound, 143-24-8, name is 2,5,8,11,14-Pentaoxapentadecane, molecular formula is C10H22O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H22O5
General procedure: General Experimental Procedure Use a 300 milliliter (mL), High Pressure HASTELLOY C-276 Parr reactor with a glass insert as a reaction vessel. Charge 90 mL of acetic acid (S.D. Fine-Chem Ltd.) into the reactor. Add a known amount of polyether polyol and/or derivative thereof to the acetic acid. Add 4 mL of a 55 % (weight/weight) aqueous solution of hydrogen iodide (HI) (Merck) or 3.73 gram (g) I2 to the reactor, then close the reactor and mount it on a reactor stand. Flush void space within the reactor two times with gaseous nitrogen (200 psig (- 1.38 MPa). Feed H2 into the reactor up to a pressure of 500 psig (~3.45 MPa) and heat reactor contents, with stirring at a rate of 1000 revolutions per minute (rpm) up to a temperature of 210 C. Add sufficient additional H2 to the reactor to increase pressure within the reactor up to 1000 psig (~6.89 MPa). After 45 minutes of reaction time, remove a sample of vapor phase within the reactor using a gas sampling vessel. Analyze the sample via gas chromatography (GC) (Agilent 7890 with two thermal conductivity detectors (TCDs) and one flame ionization detector (FID)). Use a PoraPlot Q (Varian CP7554) column to separate carbon dioxide (C02), olefins and alkanes. Use a CP Wax (Varian CP7558) column to separate oxygenates and a molecular sieve (Molsieve) (Varian CP7539) column to separate hydrogen, nitrogen and lower hydrocarbons. The reaction is continued in this fashion for a desired period of time. Based upon the vapor phase composition, calculate the mole percent (mol ) of polyol present in the crude stream corresponding to the olefin formed. The liquid phase is analyzed on GC (Liquid sample GC analysis is carried out using an Agilent 7890 gas chromatogram fitted with a split-splitless capillary injector with a split injector liner, tapered, low pressure drop with glass wool and flame ionization detector. The injection volume used is 1 microliter and split ratio is 1:20. The GC method uses a combined DB1701 and HP5 GC columns. Samples are injected using an Agilent 7683B auto injector. Example 5 Replicate Example 1, except substitute 0.66 moles of tetraethylene glycol monomethyl ether (TEGMME) for the DEG; HI (0.029), AcOH (90 mL), T (210 C), time (360 min), H2 (300 psig). After 360 minutes, conversion of TEGDME is 26 , with selectivity to ethylene, ethane and C02 being 82, 18 and 0 %, respectively.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 143-24-8, its application will become more common.
Reference:
Patent; DOW GLOBAL TECHNOLOGIES LLC; DESHPANDE, Raj; DAVIS, Paul; PANDEY, Vandana; KORE, Nitin; BRIGGS, John R.; WO2013/90077; (2013); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem