Related Products of 41365-75-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41365-75-7, name is 1-Amino-3,3-diethoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of (S*)-3-ethyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid (75 mg, 0.23 mmol) in DMF (1 ml.) was added sequentially HATU (131 mg, 0.346 mmol) and DIPEA (0.101 ml_, 0.576 mmol). The reaction was stirred for 1 min then 3,3-diethoxypropan-l-amine (available from commercial suppliers such as Sigma Aldrich, 0.041 ml_, 0.25 mmol) was added. The reaction was stirred for 1 h, after which sat. LiCI (aq) and EtOAc were added and the layers separated. The aqueous layer was extracted with further EtOAc. The organic layers were combined, back extracted with sat. LiCI (aq) and water and filtered through a cartridge fitted with a hydrophobic frit. The filtrate was evaporated in vacuo to give a dark oil. This oil was purified using silica gel column chromatography eluting with a gradient of 50-100% EtOAc : cyclohexane and the appropriate fractions collected and concentrated in vacuoto yield (S*)-A5-(3,3-diethoxypropyl)-3-ethyl-/V7-methyl-3-phenyl- 2,3-dihydrobenzofuran-5,7-dicarboxamide (116 mg, 0.230 mmol, 100 % yield) as a pale yellow oil. LCMS (method Formic): Retention time 1.12, [M+H]” = 499 (formate)
The synthetic route of 1-Amino-3,3-diethoxypropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LUCAS, Simon Christopher Cranko; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (89 pag.)WO2019/68782; (2019); A1;,
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