In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20469-65-2 as follows. Safety of 1-Bromo-3,5-dimethoxybenzene
To a solution of 1 (25.0 g, 115.18 mmol) in DCM (200 mL) was added dropwise BBn (21.45 mL, 230.35 mmol) at 0 C, and the mixture was stirred at 25 C for 16 h. The reaction was quenched by MeOH (50 mL) and concentrated under vacuum to afford 2 (21.7 g, 99.7%) as a red oil, which was used directly without further purification.
According to the analysis of related databases, 20469-65-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; DRAGOVICH, Peter; PILLOW, Thomas; BLAKE, Robert Anthony; WERTZ, Ingrid; (619 pag.)WO2020/86858; (2020); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem