Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C18H21NO4
In a three-necked flask equipped with a stirrerDOTA (20 g, 0.05 mol),Thionyl chloride (200 ml)Stirring, heating reflux 4h,After cooling, the dichlorosulfone liquid was distilled off under reduced pressure,Then, 100 ml of dry THF was added, the solvent was distilled off under reduced pressure,To give solid acid chloride.The resulting solid acid chloride was dissolved in 250 ml of dry dichloromethane,Adding 20 ml of diisopropylethylamine,Stir,Ice bath to join(Z)-1- (3,4,5-trimethoxyphenyl) -2- (3-hydroxy-4-methoxyphenyl) ethylene (4 g, 0.0125 mol), the ice bath was removed and the temperature was gradually raised to 30 C. 3h, TLC tracking.After the reaction, add ice water 100ml, stirring 30min, vacuum distillation of organic solvents. In the aqueous phase with concentrated hydrochloric acid to adjust the pH to 2, a solid precipitation, filtration to obtain a white solid,Recrystallization from an ethanol-water solution gave 22.8 g of the desired product in 65% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang Dade Pharmaceutical Group Co., Ltd.; Wang Jianping; Wang Jianguo; (23 pag.)CN104447598; (2017); B;,
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