Reference of 366-99-4, These common heterocyclic compound, 366-99-4, name is 3-Fluoro-4-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Was added in a 500 mL reaction flask3-fluoro-4-methoxyaniline(30 g, 0.21 mol) and dichloromethane(100 mL).The ice bath was cooled to below 5 ° C,Acetic anhydride was slowly added dropwise(22 mL, 0.23 mol),The temperature of the reaction solution was controlled at 30 ° C or lower,About 1 hour period.Remove the ice bath,After stirring at room temperature for 5 hours,N-Hexane (300 mL) was added to the reaction solution,A large number of solid precipitation.After stirring for 1 hour,The filter cake was washed with n-hexane,30 degrees vacuum drying,To give the title compound (whiteColor solid powder, 28 g, 72percent).
The synthetic route of 366-99-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhang, Ruihao; (36 pag.)CN105949178; (2016); A;,
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