Electric Literature of 22236-08-4, These common heterocyclic compound, 22236-08-4, name is 3-(Difluoromethoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A round bottom flask was charged under argon with aniline 3(1.0 equiv.), aldehyde 4 (1.0 equiv.), and tetronic acid 5 (1.0 equiv.) in2-pentanol or ethanol [0.3 M]. Reaction was refluxed (at 125 C or 80 C respectively) for 1 h, then the solvent was evaporated undervacuum and the crude product purified by recrystallization inethanol or by flash chromatography on silica gel
The synthetic route of 22236-08-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jeedimalla, Nagalakshmi; Flint, Madison; Smith, Lyndsay; Haces, Alberto; Minond, Dmitriy; Roche, Stephane P.; European Journal of Medicinal Chemistry; vol. 106; (2015); p. 167 – 179;,
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