Adding a certain compound to certain chemical reactions, such as: 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89282-70-2, Recommanded Product: 89282-70-2
A mixture of phenyl 5-({trans-4-[(2-chloro-4-fluorophenyl)carbamoyl]cyclohexyl}carbamoyl)-1 H-imidazole-4-carboxylate (150 mg, 0.309 mmol,) and 2-methoxy-2-methylpropan-1 -amine(160 mg, 1.55 mmol, GAS No 89282-70-2) in tetrahydrofuran (4.8 ml) was stirred at 600over night. For work-up, the reaction mixture was concentrated and the residue was purified by flash chromatography (25 g Snap Cartridge, ethyl acetate/ethanol gradient, 0% -> 5% ethanol) to yield the title compound (18.0 mg, 12 yield).[C-MS (Method 6): R = 1 .08 mm; MS (ESIpos) m/z = 494.2 [M+H].1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 13.20-12.45 (m, 1H), 11.43-1 0.70 (m, 1H), 9.52 (s,1H), 8.69-7.89 (m, 1H), 7.82 (s, 1H), 7.65-7.57 (m, 1H), 7.53-7.47 (m, 1H), 7.27-7.18 (m,1H), 3.89-3.66 (m, 1H), 3.37 (d, 2H), 3.15 (s, 3H), 2.48-2.38 (m, 1H), 2.10-1.75 (m, 4H),1.71 -1 .32 (m, 4H), 1.14 (s, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxy-2-methylpropan-1-amine, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
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