These common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of (4-(Trifluoromethoxy)phenyl)methanamine
A mixture of 4,7-dichloro-l-methyl-lH-pyrrolo[2,3-c]pyridine (153 mg, 760 muiotaetaomicron) obtained in Reference example 2 and 4-(trifluoromethoxy)benzylamine (1.45 g, 7.60 mmol) was stirred at 200C for 6 hours under microwave irradiation. After cooling, to the reaction solution was added 1 mol/L aqueous citric acid solution, and the mixture was extracted with ethyl acetate twice. The organic layer was combined, washed with water, filtered through diatomite column, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 19:1?1 : 1) to give 4- chloro- 1 -methyl -N- [4-(trifluoromethoxy)benzyl] – 1 H-pyrrolo [2,3 -c]pyridine-7-amine (138 mg, 51%) as a yellow viscous material.APCI-MS m/z:356/358[M+H]+.
The synthetic route of (4-(Trifluoromethoxy)phenyl)methanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; TSUZUKI, Yasuyuki; SAWAMOTO, Daisuke; SAKAMOTO, Toshiaki; KATO, Taku; NIWA, Yasuki; AWAI, Nobumasa; WO2012/124825; (2012); A1;,
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