Adding a certain compound to certain chemical reactions, such as: 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4393-09-3, name: (2,3-Dimethoxyphenyl)methanamine
General procedure: Under an atmosphere of N2, the appropriate amine (0.669 mmol, 1.2 equiv.) was dissolved in 1,2-dichloroethane (DCE) (1 mL) and methyl-(E)-3-(4-formylphenyl)acrylate (106 mg; 0.557 mmol, 1 equiv.) wasthen added, followed by the addition of acetic acid (64 muL, 1.11 mmol, 2 equiv.). The reaction mixture wasstirred overnight at room temperature. When the starting aldehyde had been consumed as monitored by TLC,NaBH(OAc)3 (0.836 mmol, 1.5 equiv.) was added, and the reaction mixture was stirred for 3 h at roomtemperature. The reaction was quenched by the addition of saturated NH4Cl solution (2.0 mL), and thenextracted with saturated sodium hydrogen carbonate solution (10 mL) and ethyl acetate (3 × 10 mL). Theorganic layer was washed with brine, dried over anhydrous magnesium sulfate, and filtered. The solvent wasremoved in vacuo, and the residue was dissolved in a minimal volume of dichloromethane (DCM) and purifiedby flash column chromatography (silica gel, 20-80% EtOAC:hexane).
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Reference:
Article; Daniel, Lydia; Gotsbacher, Michael P.; Richardson-Sanchez, Tomas; Tieu, William; Codd, Rachel; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2581 – 2586;,
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