Synthetic Route of 105404-89-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of 2,7-dibromonaphthalene (300 mg, 1.05 mmol) in1,4-dioxane (10 mL) were added 4-nitrophenylboronic acid (381 mg, 2.28 mmol), Pd(PPh3)4 (28 mg, 0.024 mmol), and aq. Cs2CO3 (2 M, 2 mL), and the reaction mixture was stirred overnight at reflux under Ar. Then, the reaction mixture was diluted with water (30 mL), and the product was extracted with chloroform (100 mL × 3). The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography [hexane/chloroform (2:1)] to give 2,7-bis(4-nitrophenyl)naphthalene 3a (326 mg, 0.879 mmol, 84%) as a yellow solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,7-Dibromo-3,6-dimethoxynaphthalene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Hachiya, Sojiro; Asai, Kengo; Konishi, Gen-Ichi; Tetrahedron Letters; vol. 54; 14; (2013); p. 1839 – 1841;,
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