Related Products of 20781-20-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20781-20-8 name is (2,4-Dimethoxyphenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of compound 58 (6.6 g, 33.5 mmol) in dichloromethane (100 mE) were added DIPEA (8.65 g, 67 mmol), HOSt (5.4 g, 36.85 mmol) and EDCI (9.6 g, 50.3 mmol). Afier about 15 mm stirring, to the homogeneous reaction mixture was added a solution of 2,4-dimethoxy- benzyl amine (5.6 g, 33.5 mmol) in dichloromethane (50 mE) dropwise under nitrogen atmosphere. The resulting mixture was stirred under nitrogen atmosphere at room temperature for 16 h. The reaction mixture was washed successively with iN NaOH (100 mE), water (100 mE) and brine (100 mE). The organic phase was then dried over Na2SO4 and evaporated to give a crude solid product 59 that crystallized from ethyl ether. Filtration and open air suction drying afforded an off-white solid pure product 9.8 g (96%), (MS: [M+1]=347).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2,4-Dimethoxyphenyl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; AgeneBio, Inc.; Mekonnen, Belew; Butera, John A.; Huang, Jianxing; (331 pag.)US2018/170941; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem