Adding a certain compound to certain chemical reactions, such as: 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7252-83-7, Application In Synthesis of 2-Bromo-1,1-dimethoxyethane
Dimethyl malonate (3.70 mL, 32.4 mmol) was added dropwise to a stirred solution of NaH(780 mg, 32.4 mmol) in DMF (50 mL) at 0 C, and the resultant mixture was stirred at 0 Cfor 1 h. KI (980 mg, 6.00 mmol) and 2-bromo-1,1-dimethoxyethane (3.50 mL, 29.6 mmol)were added and the resultant mixture was allowed to warm to rt, then heated at 100 C for24 h. Saturated aq NH4Cl (30 mL) was added and the resultant mixture was extracted withCH2Cl2 (4 × 70 mL). The combined organic extracts were dried over MgSO4, thenconcentrated in vacuo. Purification via flash column chromatography (petrol/Et2O, 2:1) gavethe title compound as a colourless oil (4.62 g, 72%), with spectroscopic data in accordancewith the literature.
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Reference:
Article; Robinson, Emily R. T.; Frost, Aileen B.; Elias-Rodriguez, Pilar; Smith, Andrew D.; Synthesis; vol. 49; 2; (2017); p. 409 – 423;,
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