Electric Literature of 36865-41-5, The chemical industry reduces the impact on the environment during synthesis 36865-41-5, name is 1-Bromo-3-methoxypropane, I believe this compound will play a more active role in future production and life.
To a solution of Intermediate 7 (4.02 g, 20.7 minol) in DMF (50 mL) sodium hydride 60% in mineral oil (992 mg, 22.7 minol) was added carefully at 0 00. The ice bath was removed and the mixture was stirred for 30 min at room temperature. The resulting suspension was cooled at 00 and 1-bromo-3-methoxypropane (2.3 mL, 20.7 minol) was added. The reaction mixture wasstirred over night at room temperature. The mixture was poured into water and extracted three times with ethyl acetate. The combined organic extracts were washes with brine, dried over Na2SO4 and evaporated. The crude material was purified by flash-chromatography on silica gel to yield the desired product (4.6 g, 85%).1H-NMR (400MHz, DMSO-d6): oe [ppm]= 1.02 (d, 3H), 1.80 (quin, 2H), 2.24 (dd, IH), 2.62 (dd, IH), 3.21 (s, 3H), 3.24-3.36 (m, 3H), 3.57-3.68 (m, IH), 3.82-3.93 (m, IH), 5.55 (s, 2H), 6.53- 6.61 (m, 2H), 7.42 – 7.56 (m, 2H).UPLO (Method 2): R = 0.79; MS (ESIpos): mz [M÷H] 276.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-methoxypropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GIESE, Anja; QUANZ-SCHOEFFEL, Maria; MUeLLER, Thomas; GUeNTHER, Judith; BOeHNKE, Niels; GRIEBENOW, Nils; BARAK, Naomi; BOeMER, Ulf; NEUHAUS, Roland; OSMERS, Maren; KOPITZ, Charlotte Christine; KAULFUSS, Stefan; REHWINKEL, Hartmut; WEISKE, Joerg; BADER, Benjamin; CHRISTIAN, Sven; HILLIG, Roman; (426 pag.)WO2018/86703; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem