Related Products of 16618-68-1,Some common heterocyclic compound, 16618-68-1, name is 3-Bromo-5-methoxyaniline, molecular formula is C7H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : Synthesis of N-(3-Bromo-5-methoxy-phenyl)acetamideTo a solution of 20 g of 3-bromo-5-methoxy-aniline in 200 mL DCM was added 27.44 mL triethylamine at 0 C .To the reaction mixture was added 7.06 mL acetyl chloride dropwise over 30 min. The reaction was stirred at 30C for 3 h, and then poured onto ice. The pH was adjusted to pH 7 with aqueous NaHC03 and the precipitated solids were removed by filtration. The aqueous was extracted with DCM and the combined organic extracts were dried over sodium sulfate, filtered and evaporated under reduced pressure to yield 20 g N-(3-bromo-5- methoxy-phenyl) acetamide as solid.Analysis: HPLC-MS: Rt = 2.44 min (method Q), M+H = 244 / 246
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-5-methoxyaniline, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; HOFFMANN, Matthias; KLICIC, Jasna; LAMB, David James; MCCARTHY, Clive; NAPIER, Spencer; PARRISH, Karen; SCOTT, John; SWANTEK FITZGERALD, Jennifer L.; WALKER, Edward; WO2015/140054; (2015); A1;,
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