These common heterocyclic compound, 38380-85-7, name is 1-Bromo-4-cyclopropoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Bromo-4-cyclopropoxybenzene
A mixture of intermediate compound 11 (2.34 mmol, 0.5 g), potassium phthalimide (2.81 mmol, 0.52 g) and copper (I) iodide (2.81 mmol, 0.54 g) in dimethylacetamide (6 mL) was refluxed under argon for 18 h. After cooling to room temperature, the reaction mixture was treated with 2N potassium hydroxide (5 mL), and partitioned with EtOAc (25 mL) and saturated 2N potassium hydroxide (25 mL). The organic layer was separated and washed with brine, dried over anhydrous magnesium sulphate, filtered and concentrated to afford 547 mg of the title compound which was precipitated in acetonitrile. The solid was filtered and washed with hexane, dried over vacuum to afford 221 mg of the pure title compound (221 mg, Yield: 34%). 1 H NMR (400 MHz, CDCI3) delta 7.98-7.95 (2H, m), 7.80-7.78 (2H, m), 7.36-7.32 (2H, m), 7.20-7.16 (2H, m), 3.80-3.75 (1 H, m), 0.82-0.81 (4H, m) LC-MS: tR= 3.55 [M+H]+ not ion (method 3).
The synthetic route of 1-Bromo-4-cyclopropoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; GARCIA GARCIA, Francisco, Javier; SALAS SOLANA, Jordi; WO2013/149996; (2013); A1;,
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