134364-69-5, name is 2,3-Difluoroanisole, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks
The arylation coupling reaction: the reaction bottle nitrogen protection, the room temperature by the addition of 32.2 g 3 – chloro -2 – fluoro anisole, 31.2 g acetyl ethyl acetate and 160 ml DMF, added after stirring […] 4 g copper acetate, heating to 50 C reaction 8 h. After the reaction into the 300 ml saturated ammonium chloride aqueous solution quenching reaction, adding 200 ml ethyl acetate extraction three times, the combined organic layer, after drying with anhydrous sodium sulfate concentrated to dry, to obtain 25.8 g intermediate VII, purity 99.3%, the weight yield of 80.2%.
The synthetic route of 134364-69-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Aoruite Pharmaceutical Co., Ltd.; Che Fengfeng; Jiang Tao; Wang Aimin; Xu Chenke; (9 pag.)CN109956906; (2019); A;,
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