Application of 43229-65-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 43229-65-8, name is N-Benzyl-1-(4-methoxyphenyl)propan-2-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[0140] General procedure for Enantiomeric Separation of 2- benzylaminopropanes [(R)-10-14, (S)-10-14]. The appropriate racemic 2- benzylaminopropane (1 eq) was combined with the appropriate optically active mandelic acid (1 eq) in methanol (c= 0.5 M) and refluxed until the solution homogenized, then cooled to RT. The crystals were filtered, collected, and recrystallized twice from methanol (c = 0.3 M) to afford the optically active 2- benzylaminopropane ? mandelic acid salt. The salts were converted to the free amine for the purpose of collecting NMR and rotation data by partitioning the mandelic acid salt between 10% K2CO3 and CHCl3, drying organic extracts (Na2SO4) and evaporating; [0143] (R)-(-)-l-(4′-Methoxyphenyl)-2-benzylaminopropane [(R)-Il]. A sample of 3.02 g (11.8 mmol) of l-(4′-methoxyphenyl)-2-benzylaminopropane (42) was reacted with 1.8 g (11.8 mmol) f5rJ-(+)-mandelic acid to give 530 mg (35% based on enantiomeric abundance) of the free amine after workup. 1H NMR (CDCl3) delta 1.10 (d, 3H, J = 6.3 Hz), 2.57-2.76 (m, 2H), 2.88-2.94 (m, IH), 3.79 (s, 3H), 3.72-3.88 (m, 2H), 6.82 (d, 2H, J = 8.7 Hz), 7.07 (d, 2H, J= 8.4 Hz), 7.15-7.31 (m, 5H); MS (APCI+) m/z (rel): 256 (100); [alpha]D = -30.4 (c = 1.25 MeOH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2008/22038; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem