Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 437-83-2, name is 3-Fluoro-2-methoxyaniline, A new synthetic method of this compound is introduced below., SDS of cas: 437-83-2
General procedure: NaNO2 (12.0 g, 173 mmol, in 40 mL of water) solution was addeddropwise to the mixture of 3-fluoro-2-methoxyaniline (20.0 g, 158 mmol) in 200 mL of hydrobromic acid (47 %) and100 mL of water at -5 ~ 0 C and stirred for 1 hour. This solution was then added slowly to the suspension of CuBr(45.2 g, 315 mmol) in 50 mL of hydrobromic acid (47 %) at 0 C. The resulting mixture was stirred at 0 C for 1 hourthen warmed to 50 C and stirred for 1 hour. The reaction mixture was poured into ice water and extracted withether (2 X 500 mL). The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentratedto give 1-bromo-3-fluoro-2-methoxybenzene.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem