Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 216067-66-2, name is O-(2,4-Dimethoxybenzyl)hydroxylamine, A new synthetic method of this compound is introduced below., Formula: C9H13NO3
INTERMEDIATE 2 Preparation of 5- (4-Formvl-phenvl)-furan-2-carboxylic acid (2, 4-dimethoxv-benzyloxv)- amide 0- (7-Azabenzotriazol-1-yl)-N, N, N’, N’-tetramethyluronium hexafluorophosphate (HATU, 6.6 g) and 5- (4-Formyl-phenyl)-furan-2-carboxylic acid (3.14 g, was made by method analogous to INTERMEDIATE 1, but suing appropriate starting material and the methyl ester was hydrolyse to the acid) were added to the solution of 0- (2, 4-Dimethoxy-benzyl)- hydroxylamine (2.64 g) and DIEA (6.26 mL) in DMF (60 mL) at 0C, and stirred at the same temperature for about 1h. After the TLC showing the substances disappeared, saturated sodium bicarbonate was added to the reaction mixture, and stirred for additional 1h, worked up to give a yellow oil. The oil was dissolved in small amount of THF, then diluted with water (the oil appeared again), under vigorous stirring ether was added, the oil solidified soon. The solid was filtered and washed with water and ether. The solid was recrystallized from methanol/ether to give 3.8 g of 5- (4-Formyl-phenyl)-furan-2-carboxylic acid (2, 4-dimethoxy-benzyloxy)-amide.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; S*BIO PTE LTD; WO2005/40161; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem