Month: May 2021

Related Products of 33170-72-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33170-72-8 as follows.

[0322] To a stirred solution of iV-hydroxy-6-methoxy-5-(4-methyl- 1H-imidazol- 1-yl) picolinimidamide (1 g, 4 mmol) in DMSO (5 mL) at 0 C under an argon atmosphere were added potassium hydroxide (272 mg, 5 mmol) and 2-bromo-1,1-dimethoxypropane (814 mg, 4 mmol). The reaction mixture was warmed to room temperature and stirred for 24 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with ice cold water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain N-((1,1- dimethoxypropan-2-yl) oxy)-6-methoxy-5-(4-methyl- 1 H-imidazol- 1 -yl) picolinimidamide Example 3 (300 mg, crude) as an off-white solid used in the next step without further purification. LCMS: 46.2%; 349.9 (M+1); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7tim); RT 1.63 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%: 0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 30% EtOAc/ hexane (Rj: 0.6)

According to the analysis of related databases, 33170-72-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 910251-11-5, The chemical industry reduces the impact on the environment during synthesis 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, I believe this compound will play a more active role in future production and life.

A vial was charged with (8-bromo-5,ll -dihydro-6H-pyrido [2,3-b] [1,5 ]benzodiazepin-6- yl)Qrans-4-methoxycyclohexyl)methanone (25 mg, 0.060 mmol), potassium trifluoro(methoxymethyl)borate (11 mg, 0.075 mmol), mesylate[(di( 1 -adamantyl)-nbutylphosphine)-2-(2?-amino- 1,1 ?-biphenyl)]palladium(II), [(di( 1 -adamantyl)-butylphosphine)-2- (2?-amino-l,l?-biphenyl)]palladium(II) methanesulfonate (4.4 mg, 6.0 jimol) and cesiumcarbonate (59 mg, 0.18 mmol). The solids were dissolved in 2-methyl-2-butanol (0.5 mL) andwater (0.125 mL), the reaction was purged under argon for 5 minutes, and then heated to 70C for 18 h. The reaction was then allowed to cool to room temperature and concentrated under reduced pressure. The residue was filtered and purified by mass triggered reverse phase HPLC (ACN/water with 0.1% TFA modifier) to afford the title compound as a solid TFA salt. MS: 382 (M + 1). ?H NMR (600 MHz, DMSO-d6) oe 9.61 (s, 1H), 8.04 – 8.00 (m, 1H), 7.51 (d, J= 7.1 Hz,1H),7.29-7.26(m, 1H),7.19-7.16(m,2H),6.76-6.71 (m, 1H),5.17 (d,J= 15.0Hz, 1H),4.33 (s, 2H), 3.88 (d, J 14.9 Hz, 1H), 3.20 (s, 3H), 3.09 (s, 3H), 2.95 – 2.85 (m, 1H), 2.38 -2.31 (m, 1H), 1.98-1.90 (m, 1H), 1.84- 1.79 (m, 1H), 1.76- 1.70 (m, 1H), 1.48-1.37 (m,1H), 1.17- 1.08 (m, 1H), 0.99 -0.90 (m, 1H), 0.86- 0.76 (m, 1H), 0.62- 0.51 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Related Products of 104197-14-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104197-14-0, name is 4-Bromo-2,6-difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(iii) 3 ,5-Difluoro-4-methoxybenzonitrileA mixture of 4-bromo-2,6-difluororhohenyl methyl ether (11.5 g, 0.0516 mol; see step (ii) above) and CuCN (6.92 g, 0.0774 mol) in dry DMF (15 mL) was stirred at 120C for two days under nitrogen atmosphere. The reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure followed by column chromatography over silica gel, using 2% ethyl acetate in petroleum ether as eluent, yielded 2.7 g of the sub-title compound as a pale yellow solid.

The synthetic route of 4-Bromo-2,6-difluoroanisole has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5111-65-9 as follows. HPLC of Formula: C11H9BrO

The B22 – 1 (1 g, 4.22 mmol) is dissolved in dioxane (5 ml) in, adding three (dibenzylidene acetone) two palladium (97 mg, 0 . 17 mmol) and 2 tert-butyl phosphine 2 ‘, 4′, 6’ – three isopropyl biphenyl (72 mg, 0 . 17 mmol), then adding dissolved in 5 ml water with potassium hydroxide (709 mg, 12 . 66 mmol), heating to 100 C reaction 1.5 hours. After cooling to room temperature by adding 2 N HCl (20 ml), stirring 1 hour after concentrating under reduced pressure, methylene chloride (30 ml * 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, concentrated under reduced pressure to get the yellow solid (435 mg, 59%).

According to the analysis of related databases, 5111-65-9, the application of this compound in the production field has become more and more popular.

Application of 67191-35-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

A flame-dried Schlenk reaction flask is charged with a stir bar and put under an Ar atmosphere. 923 mg [Dichloro-(3-phenyl-1H-inden-1-ylidene)-bis-(tricyclohexyl-phosphine)-ruthenium(II)] 2a (1.0 mmol; Umicore AG & Co KG, Hanau), 173 mg 2-isopropoxystyrene (1.05 mmol; 1.05 equiv.; Aldrich) and 1026 mg Amberlyst 15-A resin in dry form (4.0 mmol, 4 equiv.; Rohm and Haas Co., Philadelphia, USA) are loaded into the reaction flask and 25 mL dichloromethane (DCM) is added. The reaction is stirred at 40 C. for 75 minutes and the solution colored from red to brown. Subsequently, the reaction mixture is sent through a Pasteur pipette equipped with a cotton plug to remove the Amberlyst resin. Evaporation of all volatiles, suspending the residue in 20 mL n-hexane and subsequent filtration and drying of the precipitate in vacuo afforded 548 mg of the desired compound 3a (yield: 91%)

The chemical industry reduces the impact on the environment during synthesis 1-Isopropoxy-2-vinylbenzene. I believe this compound will play a more active role in future production and life.

Synthetic Route of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a round bottomed flask, diol 7 (1.03 g 8.8 mmol) was dissolved in 90 mL of DCM. Triethylorthobenzoate (3.0 mL,13.5 mmol) and p-toluenesulfonic acid (32.0 mg 2 molpercent) were added. The reaction mixture was stirred at room temperature for one hour. Water (0.4 mL) was added and the mixture stirred vigorously for an additional 40 minutes. The solvent was removed in vacuo, and the residue waspurified by silica gel column chromatography using 25percent ethyl acetate/hexanes as the eluent. Benzoate 10(1.02 g, 52percent) was obtained as a yellow oil. 1H-NMR (500 MHz, CDCl3): delta 2.15-2.20 (t, J=6.0 Hz, 1H),3.71-3.78 (dd, J=6.0, 12.0 Hz, 1H), 3.78-3.84 (dd, J= 5.0, 12.0 Hz, 1H), 3.86-3.93 (quin, J=5.0 Hz, 1H),4.44-4.51 (dd, J=7.0, 12.0 Hz, 1H), 4.53-4.59 (dd, J=4.5, 12.0 Hz, 1H), 7.44-7.50 (dd, J=5.0 Hz, 7.0 Hz,2H), 7.57-7.62 (t, J=7.5 Hz, 1H), 8.03-8.09 (d, J=7.5 Hz, 2H).

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-methoxy-6-methylphenylaniline (137 mg) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to a solution of triphosgene (119 mg) in anhydrous dichloromethane (5 mL) at room temperature. After the dropwise addition was completed, a solution of 1-(2-methoxy-5-methyl-phenyl)-3-(4-piperazin-1-yl-phenyl)-urea (340 mg) obtained in Example (47a) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to the reaction mixture at room temperature. After 3 hours, the reaction mixture was concentrated and diluted with ethyl acetate and water. The deposited solid was collected by filtration, washed with hexane and ethyl acetate and dried under reduced pressure, and 361 mg (72%) of the title compound was obtained as a white powder. 1H-NMR spectrum (400MHz,DMSO-d6):delta(ppm)=9.10(1H, s), 8.07(1H, s), 7.99(1H, d, J=1.5Hz), 7.77(1H, s), 7.34(2H, d, J=8.6Hz), 7.10(1H, dd, J=7.9 and 7.9Hz), 6.96(2H, d, J=9.0Hz), 6.96(1H, d, J=9Hz), 6.88(1H, dd, J=7.4 and 7.4Hz), 6.82(1H, dd, J=8.4 and 8.4Hz), 6.72(1H, d, J=8.2Hz), 3.84(3H, s), 3.73(3H, s), 3.59(4H, t, J=4.1Hz), 3.07(4H, t, J=5.1Hz), 2.23(3H, s), 2.12(3H, s). MS(FAB) m/z:504 (M + H)+. Melting point: 200-203C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Electric Literature of 18800-30-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: b) 52.0 g (186 mmol) of 1 -bromo-4-(2-bromoethoxy)benzene is added to 300 ml THF and chilled to 0 C. Within 30 min 25.0 g (223 mmol) KOtBu are added to this mixture in several portions. The cooling bath is removed and the reaction mixture is stirred at r.t. over night. The reaction is queched by the addition of water. The resulting mixture is extracted with EtOAc (2x). The org. phases are combined, washed with sat. aq. NaCI solution, dried with MgSO4 and the solvent is removed in vacuo. The resulting product is used without further purification.

The synthetic route of 1-Bromo-4-(2-bromoethoxy)benzene has been constantly updated, and we look forward to future research findings.

Electric Literature of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2- [1- (2- {4- [1- (4,4-dimethyl-4,5-211-oxazol-2-yl) -1-methyl-ethyl] } -piperidin-4-yl] -1H-benzimidazole was dissolved in 60 mL of THF, and 620 mg of sodium methoxide was added in portions to produce a large amount of air bubbles. The solution was clouded by clarification, After 2 h of reaction, the mixture was heated to 70 C, 2032 muL 2-bromoethyl ether was added, Reaction 2 h, TLC monitoring reaction, After stopping the reaction, add a small amount of water to quench the reaction, concentrate out of THF, add methylene chloride and wash with saturated NaCl solution three times, the organic layer was concentrated with the appropriate amount of dichloromethane to dissolve it, adding n-hexane beating to obtain light yellow solid, Filtration and drying gave solid 2. 0 g, yield 90%

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.

Synthetic Route of 53087-13-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53087-13-1 name is 1-(Benzyloxy)-3-bromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-Benzyloxy-3-bromobenzene (10.56 g, 40.13 mmol), 3,5-dimethoxybenzaldehyde (7.34 g, 44.14 mmol), and n-butyl lithium (17.66 ml, 44.14 mmol) were treated in the same manner as described above for the synthesis of (2,3-dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanol. The crude material was purified via flash column chromatography (10% EtOAc in hexane gradient to 40% EtOAc in hexane in about 40 min.) to give (3-Benzyloxy-phenyl)-(3,5-dimethoxy-phenyl)-methanol as an oil (11.54 g, 82%): 1H-NMR (CDCl3) 7.43-7.21 (m, 6H, Ar), 7.04-6.85 (m, 3H, Ar), 6.54 (d, J=2 Hz, 2H, Ar), 6.36 (t, J=2 Hz, 1H, Ar), 5.72 (d, J=3 Hz, 1H, CHOH), 5.04 (s, 2H, CH2), 3.76 (s, 6H, 2OCH3), 2.21 (d, J=3 Hz, 1H, OH). The product was carried over to the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Benzyloxy)-3-bromobenzene, and friends who are interested can also refer to it.