Month: May 2021

Electric Literature of 450-88-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 450-88-4 name is 1-Bromo-4-fluoro-2-methoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1; Preparation of 5-(1,3-dihydroisoindol-2-ylcarbonyl)-3-(3-methylbenzyl)-6-hydroxy-1H-indazole (?A1?); 1.1; 12 ml of dichloromethane are added to 3.25 g of aluminium chloride under argon, and the mixture is cooled to -55 C. with stirring. A solution of 2.5 g of 2-bromo-5-fluoroanisole and 2.47 g of m-tolylacetyl chloride in 8 ml of dichloromethane is added dropwise at this temperature. The mixture is stirred for a further 10 minutes, allowed to warm slowly to 0 C. and subsequently hydrolysed using 1N HCl. The mixture is stirred for a further 15 minutes, diluted with dichloromethane and subjected to conventional work-up. The residue obtained is digested with petroleum ether/diethyl:ether (8:2), filtered off with suction and rinsed with petroleum ether. Drying gives 1.85 g of ?1a?

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-fluoro-2-methoxybenzene, and friends who are interested can also refer to it.

Related Products of 3616-56-6, These common heterocyclic compound, 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis example B6: Synthesis of 12H-benzofuranyl[3,2-a]carbazole (compound 6); (6); Compound 5 (2.8 g, 1 eq.) is added to acetic acid (30 ml) and heated to reflux. (Dimethylamino)acetaldehyde diethyl acetal (95percent; 20.3 g, 10 eq.) is added dropwise in portions to the solution. The reaction is stirred at reflux overnight. Then further (dimethylamino)acetaldehyde diethyl acetal (95percent; 2.0 g) is added and stirred further at reflux after 3 h. Subsequently, the flask contents are diluted with CH2CI2 at room temperature and washed in a separating funnel with distilled water and NaCI (saturated). Organic phase is dried with Na2S04 and concentrated. LC (Si02, 15:85 ethyl acetate/cyclohexane) gives the product 6 (1 .92 g, 62.2percent yield).1 H NMR (CD2CI2, 400 MHz): “5 = 8.88 (br s, 1 H), 8.16 (d, 1 H), 8.12 (d, 2H), 7.66 (d, 1 H), 7.62 (d, 1 H), 7.42-7.53 (m, 4H), 7.31 (dd, 1 H).

The synthetic route of 3616-56-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 89521-55-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89521-55-1 as follows.

Example 1 Preparation of 4-benzyloxybenzimidazole STR109 A mixture of 3-benzyloxy-1,2-diaminobenzene 1.6 g (0.0073 mol) and formic acid (2.6 g, 0.057 mol) was heated to reflux for 1.5 h. The resulting mixture was then cooled, dissolved in methylene chloride, washed with 10% sodium carbonate solution, dried (Na2 SO4) and evaporated to dryness in vacuo. The residue was recrystallized from acetonitrile to give the title compound in 0.75 g (46%) yield, m.p. 165-167 C.

According to the analysis of related databases, 89521-55-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70384-51-9, name is Tris(2-(2-methoxyethoxy)ethyl)amine, A new synthetic method of this compound is introduced below., COA of Formula: C15H33NO6

EXAMPLE 61 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(6-chloro-pyrimidin-4-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one A mixture of 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (0.1 g, 0.21 mmol), potassium carbonate (59 mg, 0.42 mmol), CuCl (2 mg, 0.021 mmol), tris[2-(2-methoxyethoxy)-ethyl]-amine (1.5 muL) and 4,6-dichloropyrimidine (32 mg, 0.21 mmol) in xylene (5 mL) was stirred and boiled for 18 h. The mixture was cooled, washed with water, ammonia in water (10percent) and water again. Evaporation of the solvent yielded a residue which was purified by chromatography on silica gel (ethyl acetate/n-hexane 1:2) to yield the desired product (29 mg, 24percent), m.p. 212-214° C. and MS: m/e=584.1 (M+H+).

The synthetic route of 70384-51-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102503-23-1, HPLC of Formula: C10H15NO2

Sodium hydride (60% in oil, 2.23 g, 55.8 mmol) was washed twice with n-hexane and suspended in THF (180 mL). A solution of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (9.09 g, 50.2 mmol) in THF (10 mL) was added dropwise to this suspension at 0 C, and then the mixture was stirred at 60 C for 18 h. After cooled to 0 C, a solution of compound 15 (9.64 g, 45.4 mmol) in THF (10 mL) was added dropwise, and then the mixture was stirred at the same temperature for 1 h. Ice-cooled solution of NaCl were added, and the mixture was extracted with EtOAc. The extract was washed successively with a solution of NH4Cl, a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (EtOAc) to obtain compound 16 (16.8 g, 99%) as a yellow oil. 1H-NMR (CDCl3) d 2.24 (3H, s), 3.51 (2H, s), 3.54 (2H, s), 3.79 (3H, s), 3.80 (3H, s), 6.45 (1H, s), 6.42-6.50 (1H, m), 6.68 (1H, dd, J = 4.7 Hz, 3.6 Hz), 7.18-7.29 (2H, m), 7.98 (1H, ddd, J = 4.5 Hz, 1.9 Hz, 1.5 Hz), 8.25 (1H, ddd, J = 10.2 Hz, 8.0 Hz, 1.9 Hz), 8.67 (1H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 33311-29-4, The chemical industry reduces the impact on the environment during synthesis 33311-29-4, name is 4-(2-Methoxyethoxy)aniline, I believe this compound will play a more active role in future production and life.

The 4-(2-methoxyethoxy)aniline used as starting material was obtained as follows: Potassium tert-butoxide (2 g) was added portionwise to a stirred mixture of 4-fluoronitrobenzene (2.8 g), 2-methoxyethanol (10 ml) and DMF (20 ml). The mixture was stirred and heated to 60 C. for 4 hours. The mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water and with brine, dried (MgSO4)- and evaporated. The residue was recrystallized from a mixture of hexane and ethyl acetate. There was thus obtained 4-(2-methoxyethoxy)nitrobenzene (1.06 g), m.p. 86 C. The product so obtained was dissolved in ethyl acetate and hydrogenated in the presence of a 10% Pd/C catalyst to give 4-(2-methoxyethoxy)aniline (0.7 g). NMR Spectrum: (CD3 SOCD3) 3.3 (s, 3H), 3.6 (t, 2H), 3.9 (t, 2H), 4.6 (s, 2H), 6.5 (d, 2H), 6.7 (d, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(2-Methoxyethoxy)aniline, other downstream synthetic routes, hurry up and to see.

Related Products of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: DBU (4.5mmol) and 1-bromo-2-methoxyethane or 1-(2?-methoxyethoxy)-2-bromoethane were added to a solution of a triterpenic acid 1, 2, 3, 4 (2.2mmol) in the mixture of CH2Cl2 (6mL) and MeCN (2mL). The reaction mixture was stirred for 2 days at room temperature. The work-up (A), column chromatography on silica gel, and crystallization afforded final products 1a – 3a and 1b – 3b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Electric Literature of 41864-45-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41864-45-3, name is 4,5-Dimethoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 18 N2-(4,5-Dimethoxy-2-methylphenyl)-N4-(5-adamantylisoxazol-3-yl)-2,4-pyrimidinediamine The title compound was prepared by the method described in Example 1 using 2-chloro-N4-(5-adamantylisoxazol-3-yl)-4-pyrimidineamine and 2-methyl-4,5-dimethoxyaniline. MS (MH+)=462.2; Calc’d for C26H31N5O3-461.57. Other compounds included in this invention are set forth in Tables 1-2 below.

The chemical industry reduces the impact on the environment during synthesis 4,5-Dimethoxy-2-methylaniline. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2734-70-5, Quality Control of 2,6-Dimethoxyaniline

Acetic anhydride (2.97 mL, 31.45 mmol) was added to a solution of aniline 51 (2.19 g, 14.3 mmol) in dry dichloromethane (50 mL) under inert atmosphere. The reaction was stirred at room temperature for 24 hours. Upon completion, the reaction mixture was washed with a saturated solution of sodium carbonate, the organic layer dried over MgSO4 and the solvent removed under reduced pressure. The acetanilide 52 was obtained as a white solid (1.67 g, 60percent) after crystallization from Et2O; mp (Et2O) 128-130 °C; TLC Rf (EtOAc) = 0.37; 1H NMR (CDCl3, 400 MHz) delta (ppm) 2.20 (large s, 3H, NHCOCH3), 3.84 (s, 6H, 2OCH3), 6.42 (large s, 1H, NHCOCH3), 6.59 (d, J = 8.4 Hz, 2H, ArH), 7.20 (t, J = 8.2 Hz, 1H, ArH). 13C NMR (CDCl3, 100 MHz) delta 23.3 (CH3), 55.9 (2CH3), 104.3 (2CH), 107.4 (C), 127.8 (CH), 155.6 (2C), 172.9 (C). IR nu cm-1: 1104, 1253, 1437, 1474, 1537, 1590, 1651, 3184, 3256. Calcd. for C10H13O3N: C, 61.53; H, 6.71; N, 7.17. Found: C, 61.36; H, 6.94; N, 7.01.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 168971-68-4, name is 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

To a solution of 1-brorno-2-fiuoro-4-(rifluorornethoxy)benzene (5.00 g, 19.31 mrnoi) in MeCN (20 inL) wasadded NO2BF4 (2.69 g. 2027 mrnoi) in portions keeping the temperature between -40 to -30 C. The mixture was stirred at between -40C to -30C for 2 h. Then the mixture was allowed to warm to rt and stirred for 18 Ii. The mixture was poured into ice, and extracted with EtOAc (3×30 mL). The combined organic layers were dried over Na2SO4, filtrated and concentrated in vacuo, The residue was purified on silica gel (PE:EtOAc=80: ito 50:1) to atihrd the title compound.

The synthetic route of 168971-68-4 has been constantly updated, and we look forward to future research findings.