Month: May 2021

Synthetic Route of 3616-56-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, This compound has unique chemical properties. The synthetic route is as follows.

Synthesis Example B2Synthesis of 12H-benzofuranyl[2,3-a]carbazole (compound 2)Compound 1 (2.0 g, 1 eq.) is added to acetic acid (90 ml) and heated to reflux. (Dimethylamino)acetaldehyde diethyl acetal (95percent; 14.6 g, 10 eq.) is added dropwise in portions to the solution.The reaction is stirred at reflux until no reactant is present any longer.Subsequently, the flask contents are diluted with CH2Cl2 at room temperature and washed in a separating funnel with distilled water and NaCl (saturated).Organic phase is dried with Na2SO4 and concentrated. LC (SiO2, 15:85 CH2Cl2/n-hex) gives the product 2 (0.85 g, 39percent yield).1H NMR (CD2Cl2, 400 MHz): delta=8.68 (br s, 1H), 8.15 (d, 1H), 8.06 (dd, 2H), 7.83 (d, 1H), 7.67 (d, 1H), 7.59 (d, 1H), 7.47 (dd, 2H), 7.41 (dd, 1H), 7.30 (dd, 1H).

The chemical industry reduces the impact on the environment during synthesis 2,2-Diethoxy-N,N-dimethylethanamine. I believe this compound will play a more active role in future production and life.

Application of 102503-23-1, The chemical industry reduces the impact on the environment during synthesis 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.

Vinylmagnesium bromide (17.7 mL of a IN solution in THF, 17.7 mmol) was added to a solution of 5 (2.00 g, 8.84 mmol) in dry THF (30 mL) at 0 C. The brown solution was warmed to r.t. for 1 h then a solution of N-methyl-2,4-dimethoxybenzylamine (4.00 g, 22.0 mmol) in THF (10 mL), and water (10 mL) were added. The solution was stirred at r.t. for 1 h, then partitioned between EtOAc and water. The solution was dried and evaporated to give a brown oil, which was chromatographed. Elution with EtOAc/hexanes gave fore fractions, then elution with EtOAc gave 7 (2.27 g, 68%) as a light yellow oil. 1H NMR (CDC13) delta 7.13 (d, J = 8.9 Hz, 1H), 6.73 (s, 2H), 6.44-6.41 (m, 2H), 3.59 (s, 6H), 3.88 (s, 3H), 3.53 (s, 3H), 3.50 (s, 2H), 3.12 (t, J = 7.0 Hz, 1H), 2.84 (t, J = 7.0 Hz, 2H), 2.26 (s, 3H). Found: [M+H]=375.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450-91-9, name is 4-Fluoro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 450-91-9

In a dry round bottom flask acetic acid (950 ml) and 4-fluoro-2-methoxyaniline (380 gms) were added. The reaction mass was stirred at 25-30°C for 10-15 minutes. Acetic anhydride (439 gms) was added slowly to the reaction mass at 25- 35°C in 1.0-2.0 hrs. The reaction mass was heated to 90°C and stirred at same temperature for 3.0-5.0 hrs. The reaction mass was decomposed into water (1000 ml) and stirred at 25-30°C for 1.0-2.0 hrs. The solid was filtered and washed with water (300 ml). The reaction mass was extracted with ethyl acetate (2000 ml). Total organic layers were washed with NaHC03 solution (NaHC03 (100 gms) + water-4 (500 ml)) followed by washed with water (1000 ml), then washed with brine solution (NaCl (50 gms) + water-6(250 ml)) and dried over sodium sulphate (200 gms). The solvent was distilled out under vacuum. Petroleum ether (500 ml) was added to the residue and cooled to below 10°C and stirred for 30 minutes. The solid was filtered off and washed with petroleum ether (150 ml). The solid was dried at 50-60°C for 3-5 hrs (Yield – 410 gms; 83.13percent).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 450-91-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873980-68-8, name is 4-Bromo-2-methoxy-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

EXAMPLE 72B N,N-dibenzyl-4-bromo-2-methoxy-5-methylbenzenamineA suspension of EXAMPLE 72A (3 g, 14 mmol), (bromo methyl)benzene (6 g, 35 mmol) and potassium carbonate (4.8 g, 35 mmol) in acetonitrile (150 mL) was heated at reflux for 20 hours. After concentration, the residue was diluted with ethyl acetate (100 mL) and washed with water (30 mL). The organic layer was dried over anhydrous sodium sulfate. filtered, concentrated and purified by flash chromatography on silica gel (200-300 mesh) eluting with 50/1 petroleum ether/ethyl acetate to give the title compound. MS: 396 (M+H+).

According to the analysis of related databases, 873980-68-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 145903-31-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145903-31-7, name is 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis of S13 and S14 (Scheme 5): To S26 (20 mg, 0.1 mmol) in CH2Cl2 (5 ml) is added triethylamine (30 mg, 0.3 mmol) and phenyl methoxyphosphonyl chloride (38 mg, 0.2 mmol) at 0 C. After stirring for 2 hours at room temperature, the reaction mixture is washed with saturated sodium bicarbonate. Isomers are separated and purified by silica gel column to yield S13 (14 mg, yield: 40%) and S14 (16 mg, yield: 45%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4393-09-3 as follows. Computed Properties of C9H13NO2

General procedure: To a solution of the acid derivative (1mmol) in CH2Cl2 were added triethylamine (2mmol) and ethyl chloroformate (1mmol), followed by stirring at 0C for 30min. After addition of the appropriate amine derivative (1.2mmol), the mixture was stirred for an additional 1h at 0C. Then, the reaction mixture was warmed to room temperature and stirred overnight. After the solvent was evaporated under reduced pressure, acetone was added, filtered, and evaporated. The residue was dissolved in CH2Cl2, and the organic phase was washed with a 1% NaHCO3 solution and brine, dried over Na2SO4, and evaporated under vacuum. The final residue was purified by flash column chromatography (Combiflash Rf) using CH2Cl2-MeOH (0-5%) as eluents. 4.3.8 (E)-N-(2,3-Dimethoxybenzyl)-3-(1H-indol-3-yl)acrylamide 3h Yield 69%, mp 211-213 C; IR (FTIR/FTNIR-ATR): 1639 cm-1 (C=O), 3206 cm-1 (N-H). 1H NMR (DMSO-d6) delta: 11.56 (1H, s), 8.21 (1H, t, J = 5.6 Hz), 7.91 (1H, d, J = 7.6 Hz), 7.75 (1H, s), 7.63 (1H, d, J = 15.6 Hz), 7.45 (1H, d, J = 7.6 Hz), 7.18 (2H, m), 6.88 (3H, m), 6.71 (1H, d, J = 16 Hz), 4.40 (2H, d, J = 6 Hz), 3.80 (3H, s), 3.76 (3H, s). 13C NMR (DMSO-d6) delta: 166.9, 152.9, 146.9, 138.0, 133.8, 133.5, 131.0, 125.5, 124.5, 122.8, 121.1, 120.9, 120.6, 116.8, 112.9, 112.8, 112.3, 60.8, 56.3, 37.7; HRMS C20H21N2O3 [M+H]+ Calcd 337.1552, Found m/z 337.1544.

According to the analysis of related databases, 4393-09-3, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 39538-68-6, name is 2-Methoxy-4-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39538-68-6, Recommanded Product: 2-Methoxy-4-methylaniline

Intermediate 43Preparation of 1-bromo-2-methoxy-4-methylbenzeneTo a solution of copper(II)bromide (6.35 g; 28.4 mmol) in acetonitrile (25 mL) was added tert-butyl nitrite (2.85 ml; 24.06 mmol) and the mixture was heated at 65 C. under nitrogen atmosphere. A solution of 2-methoxy-4-methylaniline (3 g, 21.87 mmol) in 25 ml acetonitrile was added carefully and the mixture was stirred for 20 min at 65 C. The solvent was removed under reduced pressure, the residue was dissolved in ethyl acetate and washed with a 5% solution of ammonia, water, a solution of EDTA, water and brine. The organic layer was dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (2-50%) in heptane furnished 2.32 g (53%) of the title compound. 1H-NMR (300 MHz, CDCl3) (ppm) delta: 6.63-6.60 (m, 3H, 3×Harom.); 3.82 (s, 3H, OCH3); 2.26 (s, 3H, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2734-70-5, name is 2,6-Dimethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Weigh 0.5 mmol of amide III-1, 1percent molar amount of palladium catalyst, 1 mmol of potassium carbonate, 0.75 mmol of 2,5-dimethoxyaniline in a Schlenk reaction tube, double-tube tube was purged with nitrogen, repeated three times, and then opened again. Nitrogen valve, add 2 ml of freshly distilled tetrahydrofuran, and close the valve. The tube was stirred at room temperature for 10 minutes and then placed at 110 ° C for 24 hours. After the completion of the reaction, TLC was plated, THF was evaporated, water was added, and water was added, and the mixture was extracted three times with ethyl acetate, and dried over anhydrous magnesium sulfate, and then evaporated to dryness to give the product white crystals: 0.385 mmol (104.5 mg). The product was N-(2,6-dimethoxyphenyl)-3-methylbenzamide in 77percent yield.

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 36865-41-5

To a solution of the compound of Reference Example 50 (114.3 mg, 0.182 mmol) in DMF (2 mL), potassium carbonate (50.3 mg, 0.364 mmol) and 1-bromo-3-methoxypropane (41.8 mg, 0.273 mmol) were added, and the mixture was stirred at 50C for 1 hour. A saturated aqueous solution of ammonium chloride was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of ammonium chloride twice and with a saturated saline solution once, then dried over sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain the title compound (121.2 mg, 95%). MS (ESI+) 700 (M+1, 68%)

The synthetic route of 36865-41-5 has been constantly updated, and we look forward to future research findings.

Related Products of 170015-99-3,Some common heterocyclic compound, 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine, molecular formula is C9H10F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S.3. (5-Chloro-thieno[2,3-d]pyrimidin-4-yl)-[2-(4-trifluoromethoxy-phenyl)-ethyl]-amine (Compound example C.5); 0.5 g (2.4 mmol) 4,5-dichloro-thieno-[2,3-d]-yprimidine are solved in 20 ml toluol. Subsequently 0.271 g (2.7 mmol) triethylamin, a catalytic amount of tetrabutyl- ammoniumiodide and 0.55 g (2.7 mmol) 2-(4-trifluoromethoxyphenyl)-ethylamin are added. The solution is heated under reflux for 6 hours, and stirred further 12 hours at room temperature. The solvent is destillated, the residue is reverted in CH2CI2 and is washed with 2N HCI and H2O. The residue is stirred and sucked off with hexane after being dryed and concentrated. The yield of compound C.5 obtained is 0.73 g (1.9 mmol, 76% of theoretical yield) and has a melting point Tmp of 77-79C. 1H-NMR (CDCI3): 8.50 (s, 1 H), 7.25 (d, 2H), 7.15 (d, 2H), 7.05 (s, 1 H), 6.55 (bs,1 H), 3.90 (t, 2H), 3.00 (t, 2H);

The synthetic route of 170015-99-3 has been constantly updated, and we look forward to future research findings.