Month: May 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41365-75-7, name is 1-Amino-3,3-diethoxypropane, A new synthetic method of this compound is introduced below., Product Details of 41365-75-7

f) Preparation of intermediate (10)H To a stirred solution of intermediate (9) (287 mmol) in CHC13 (2000 ml) was added 3,3-diethoxy-l-propanamine (474 mmol) at 0C in portions. After the addition, the reaction mixture was stirred at 0C for 1 hour and then at 15C for 2 hours. Thin Layer Chromatography (petroleum ether/ethyl acetate= 5/1) showed that the reaction was completed. The reaction mixture was washed by saturated Na2S03 aqueous (four times with 600 ml) and then saturated NaHC03 aqueous was added until pH = 7. The aqueous layer was extracted by CH2C12 (500 ml). The combined organic phases were washed with brine (800 ml), dried over Na2S04 and concentrated to give the crude product. The crude product was washed by tert-butyl methylether (three times 500 ml) to give 87 g of intermediate (10) (mp. 100.8 – 103.8C).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 1663-61-2, The chemical industry reduces the impact on the environment during synthesis 1663-61-2, name is (Triethoxymethyl)benzene, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of arylsulfonyl hydrazine (10 mmol),ortho ester (12 mmol), and acetic acid (1 mmol) was stirred at 80-90 °C for 12h. The reaction mixture was diluted with MeOH (50 mL). The precipitate wascollected by filtration and purified by column chromatography on silica gel(50percent EtOAc:50percent hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Triethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.

Related Products of 59557-91-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59557-91-4 name is 4-Bromo-2-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 62 5-(2,3-dichlorobenzyl)-7-{ [2-methoxy-4-(piperidin-4-yl)phenyl]amino} [l ,2,4]triazolo[4,3- c]pyrimidine-8-carboxamide Example 62A feri-butyl 4-(4-amino-3-methoxyphenyl)-5,6-dihydropyridine-l(2//)-carboxylate A mixture of 4-bromo-2-methoxybenzenamine (1.21 g, 6.0 mmol), tert-butyl 4- (3,3,4,4-tetramethylborolan-l -yl)-5,6-dihydropyridine-l (2//)-carboxylate (1.95 g, 6.3 mmol), sodium carbonate (1 .91 g, 18 mmol) and 1 , 1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.22 g, 0.3 mmol) in dioxane (25 mL) and water (5 mL) was degassed with nitrogen and heated to 90C for 15 hours. After cooling to ambient temperature, the mixutre was filtered, concentrated and purified by flash chromatography eluting with 200: 1 dichloromethane:methanol to give the title compound. MS: 305 (M+Hf).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-methoxyaniline, and friends who are interested can also refer to it.

Related Products of 24988-36-1, The chemical industry reduces the impact on the environment during synthesis 24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

25 parts of the compound represented by the formula (1-52) is converted into tetrahydrofuran.(Kanto Chemical Co., Ltd.)It was dissolved in 111 parts, cooled to -78 C., and while stirring, 234.2 parts of a 2.5 M hexane solution of n-butyllithium (manufactured by Aldrich Co.) was added dropwise.After input,Stir for 45 minutes at -78 C,With cooling to -78 C., 156 parts of iodomethane (manufactured by Tokyo Chemical Industry Co., Ltd.) was added dropwise.After input,It heated up to 23 degreeC and stirred for 5 hours.After the reaction,The reaction mixture was gradually added to 500 parts of ice water.After that, extract with water-toluene solvent,After concentration, 21 parts of crude product was obtained.This crude product is separated and purified by silica gel column chromatography,17 parts of the compound represented by the formula (1-53) were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dibromo-2,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Related Products of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 213 1-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-2-propanone hydrochloride A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (7.45 g, 33.4 mmol), K2 CO3 (5.5 g) and bromo-2,2-dimethoxypropane (6.84 g, 37.6 mmol) in acetonitrile (200 ml) was heated and stirred at reflux for 4 hours. An additional charge of bromo-2,2-dimethoxypropane (5.1 g, 28 mmol) was added and the mixture was refluxed overnight. After being cooled to room temperature, the mixture was filtered, and the solvent was removed on a rotary evaporator. The residue was purified by flash chromatography over a silica gel column (SiO2, 100 g; eluted with dichloromethane, DCM, and 1% CH3 OH in DCM). The oil product thus obtained weighed 2.2 g (24%). The oil product was dissolved into ethanol (10 ml) then was treated with HCl in ether solution (1M, 9 ml) at room temperature. The crystals were collected, 2.08 g, m.p.=220-223 C. dec. Analysis: Calculated for C15 H17 FN2 O2.HCl: 57.60% C 5.80% H 8.96% N Found: 57.49% C 5.97% H 8.67% N

The synthetic route of 126-38-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 3401-47-6, These common heterocyclic compound, 3401-47-6, name is 1-Bromo-2-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The mixture of anisole(1c, 0.216 mg, 2 mmol) and acetyl chloride (2a, 0.157 mg, 2 mmol) was treated with CTAB/CTAC, (0.001 mol), in dichloroethane and the resulting reaction mixture was heated in a controlled microwave synthesizer (BiotageInitiator+SP Wave model (0.200W at 2.45 GHz, capped at 60W duringsteady state) for 5 min (attains temperature 100 C and 2 bar pressure). The final product (3o) was isolated by absorbing the reaction mixture into silica geland purifying it by column chromatography using ethyl acetate-petroleumether as the eluent.

Statistics shows that 1-Bromo-2-methoxynaphthalene is playing an increasingly important role. we look forward to future research findings about 3401-47-6.

Adding a certain compound to certain chemical reactions, such as: 1077-01-6, name is 1-Fluoro-3-(trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1077-01-6, Recommanded Product: 1-Fluoro-3-(trifluoromethoxy)benzene

To a 100 mL round-bottomed flask were added concentrated H2SO4 (25 mL), fuming HNO3 (25 mL), and 1-fluoro-3-(trifluoromethoxy)benzene (9.0 g, 50 mmol) at -10 C. in sequence. The mixture was stirred at rt for 30 min then poured onto ice and extracted with EtOAc (3*20 mL). The combined organic layers were washed with saturated aqueous NaHCO3 solution (30 mL), brine (30 mL), dried over anhydrous Na2SO4, concentrated to dryness, and purified by FCC to give the title compound as a pale-yellow oil (0.50 g). 1H NMR (300 MHz, CDCl3): delta 8.21-8.14 (m, 1H), 7.21-7.12 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-3-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H8BrFO

C) 1-(2-(4-Fluorophenoxy)ethyl)-4-(4-nitrobenzyl)piperidine hydrobromide. This compound was prepared in a manner similar to example 25. From 4-(4-nitrobenzyl)piperidine hydrochloride (427 mg, 1.66 mmol) and 2-(4-fluorophenoxy)ethyl bromide (381 mg, 1.74 mmol) there was obtained the hydrobromide salt as a pale beige powder (510 mg, 94%): mp 147-148 C.; 1 H NMR (CDCl3) 1.65-1.89. (m, 3 H), 2.20 (q, J=12 Hz, 2 H), 2.69-2.90 (m, 4 H), 3.35-3.45 (m, 2 H), 3.73 (d, J=12 Hz, 2 H), 4.55 (t, J=3.6 Hz, 2 H), 6.77-7.04 (m, 4 H), 7.30 (d, J=8.4 Hz, 2 H), 8.16 (d, J=8.4 Hz, 2 H), 11.75 (bs, 1 H). Anal. Calcd for C20 H24 BrFN2 O3: C, 54.68; H, 5.51; N, 6.38. Found: C, 54.67; H, 5.36; N, 6.29.

The synthetic route of 332-48-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16728-64-6, name is 3-(Benzyloxy)propan-1-amine, A new synthetic method of this compound is introduced below., Quality Control of 3-(Benzyloxy)propan-1-amine

a) 4-[N-(3-Benzyloxypropyl)aminomethyl]-2′-cyanobiphenyl A solution of 6.0 g (22 mmol) of 4-bromomethyl-2′-cyanobiphenyl, 5.8 g (35 mmol) of 3-benzyloxypropylamine and 3.6 g of triethylamine in 50 ml of 1,4-dioxane is heated to boiling under reflux for 18 hours.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H7F3N2O

[0373] Compounds 41 and 100: To a mixture of Comp-41a and Comp-lOOa mixture (0.3 g, 1.31 mmol) and Comp-3b (0.29 g, 1.31 mmol) was added i-BuOk (1 mL, 1M in THF) and the reaction mixture was heated at 50 C for 16 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was diluted with w?ater and extracted with EtOAc (50 mL X 2). The organic layer was washed with water, brine, separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude obtained was purified by prep HPLC purification to afford a mixture of regioisomers (E)-2-(2-(2,5- dimethyl-l-(l-methylpiperidin-4-yl)-lH-pyrrol-3-yl)vinyl)-7-(trifluoromethoxy)quinoxaline and (E)-2-(2-(2,5-dimethyl-l-(l-methylpiperidin-4-yl)-1H-pyrrol-3-yl)vinyl)-6- (0655) (trifluoromethoxy)quinoxaline (41 and 100, respectively; 0.09 g, 17%) as a yellow solid. (0656) [0374] HPLC purity : 98.19% (0657) [0375] MS (ESI) m/e [M+H]+/Rt/%: 431.20/1.69/97.8% (0658) [0376] 1H NMR (400 MHz, DMSO-d6, 2: l mixture of isomers) delta 1.73 (d, J=l 1.25 Hz, 2H), 2.01 – 2.11 (m, 2H), 2.14-2.17 (m, 2H), 2.23 (s, 3H), 2.29 (s, 3H), 2.44 (s, 3H), 2.91 (d, J=10.27 Hz, 2H), 3.92 – 4.02 (m, 1H), 6.24 (s, 1H), 6.85 (d, J=15.65 Hz, 1H), 7.62 – 7.78 (m, 1H), 7.85 (s, 1H), 7.91 – 7.98 (m, 1H), 8.04 – 8.13 (m, 1H), 9.24 & 9.28 (s, 0.56H & 0.34H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.