Month: May 2021

Related Products of 10484-56-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10484-56-7 name is 2-Butoxynaphthalene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A flame dried Schlenk flask was charged with Bi(OTf)3 (13.1 mg,0.020 mmol), alkyl aryl ethers (0.40 mmol), alcohols or thiols (1.2 mmol) andCH2ClCH2Cl (0.20 mL), and then the resulting mixture was stirred at 110 C (or 130 C forthe synthesis of 1m) for 24 h. The solvent was removed under the reduced pressure, andthe residue was subjected to flash column chromatography on silica gel with hexane /AcOEt as eluents to afford the corresponding aryl ethers or aryl thioethers

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Butoxynaphthalene, and friends who are interested can also refer to it.

Application of 13985-15-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13985-15-4 name is 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

FIG. 17 shows schematically the methods by which the substituted precursor compounds were prepared. The tested products are labelled CMR 1 (R1-R4=-OCH3); CMR 4 (R1-R4=-CO2CH3); and CMR 6 (R1-R4?N-substituted cyclic imido).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, and friends who are interested can also refer to it.

Synthetic Route of 15799-79-8, The chemical industry reduces the impact on the environment during synthesis 15799-79-8, name is 3-Methoxy-N,N-dimethylaniline, I believe this compound will play a more active role in future production and life.

[0109] (R)-3-(4-Nitro-phenyl)-3-(4-dimethylamino-2-methoxy-phenyl)-propionaldehyde (Table 1, entry 9): To a 2-dram vial equipped with a magnetic stir bar was added (2S,5S)-5-benzyl-2-tert-butyl-3-methylimidazolidin-4-one (24.6 mg, 0.100 mmol, 0.100 equiv), N,N-dimethyl-m-anisidine hydrochloride (18.8 mg, 0.100 mmol, 0.100 equiv), CH2Cl2 (1.00 ml), and N,N-dimethyl-m-anisidine (425 uL, 2.90 mmol, 2.90 equiv). The solution was cooled to -10o C. before p-nitro-cinnamaldehyde (177 mg, 1.00 mmol, 1.00 equiv) was added as a solid. After 48 h, the reaction mixture was subjected directly to silica gel chromatography. Gradient elution with 10-50% EtOAc in hexanes followed by concentration in vacuo afforded the product as a bright orange oil in 87% yield (285 mg, 0.867 mmol); 92% ee. IR (film) 2938, 2894, 2837, 2726, 1722, 1614, 1516, 1345, 1241, 1120, 1033, 980.1, 858.6, 814.9 cm-1; 1HNMR (300 MHz, CDCl3) ?9.74 (t, J=1.9 Hz, 1H, CHO), 8.12 (td, J=2.2, 9.3 Hz, 2H, ArH), 7.42 (td, J=1.5, 9.3 Hz, 2H, ArH), 6.97 (d, J=8.3 Hz, 1H, ArH), 6.30 (dd, J=2.5, 8.8 Hz, 1H, ArH), 6.24 (d, J=2.2 Hz, 1H, ArH), 4.98 (t, J=7.8 Hz, 1H, ArCH), 3.79 (s, 3H, OCH3), 3.21-3.09 (m, 2H, CH2CO), 2.96 (s, 6H, N(CH3)2); 13C NMR (75 MHz, CDCl3) ?201.2, 157.8, 152.3, 151.4, 146.5, 128.9, 128.6, 123.8, 118.0, 104.8, 96.4, 55.4, 48.4, 40.8, 38.2. HRMS (CI) exact mass calcd for (C18H20N2O4) requires m/z 328.1423, found m/z 328.1422. [?]D=0.58.1 (c=1.0, CHCl3). [0110] The enantiomeric ratio of the product was determnined by HPLC analysis of the corresponding alcohol (obtained by NaBH4 reduction of the aldehyde) using a Chiracel AD and AD guard column (10% ethanol/hexanes, 1 mL/min); R isomer tr=25.6 min, S isomer tr=29.5 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Application of 126940-10-1, A common heterocyclic compound, 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, molecular formula is C8H9FO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a flame dried 100mL flask were added 1,3-disustituted benzene (3.0mmol), TMEDA (1.1equiv, 3.3mmol), DIPA (5%equiv, 0.16mmol), and THF (10.0mL). The solution was cooled to -78C for 10min and then n-BuLi (1.1equiv, 3.3mmol) was added dropwise. The mixture was kept at this temperature for 1h; DMF (1.5equiv, 4.5mmol) was added and the mixture was further stirred for another half an hour at -78C. The mixture was allowed to warm up to room temperature and quenched by the addition of saturated NH4Cl-H2O solution (5mL); extracted three times with ethyl acetate (10mL×3). The combined organic layers were dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The regioselectivity of the crude product was ascertained by 19F NMR (for fluorinated products) or by GC/MS (for nonfluorinated ones) and then subjected to flash chromatography to obtain the desired products which were characterized by 1H NMR, 19F NMR, and 13C NMR spectral data and GC-MS analyses.

The synthetic route of 126940-10-1 has been constantly updated, and we look forward to future research findings.

Reference of 53903-49-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53903-49-4, name is 4-Methoxy-2-(trifluoromethyl)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(c) 4-Methoxy-6-(methylthiomethyl)-2-(alpha,alpha,alpha-trifluoromethyl)aniline was prepared by substituting 4-methoxy-2-(alpha,alpha,alpha-trifluoromethyl)aniline as follows: In a 250 ml three-necked flask equipped with an overhead stirrer was placed 20.12 g (0.105 mol) of 4-methoxy-2-(alpha,alpha,alpha-trifluoromethyl)aniline in 100 ml of methylene chloride. To the solution was then added 15.63 g (0.117 mol) of N-chlorosuccinimide was added with vigorous stirring. After cooling to 0 C. under a nitrogen atmosphere, a solution of 9.2 ml (8.02 g, 0.129 mol) dimethylsulfide in 40 ml of methylene chloride was then added over a one hour period while maintaining the temperature below 5 C. The reaction mixture became very thick. The ice bath was removed and after stirring at room temperature for one hour, 200 ml of ice cold 5% aqueous sodium hydroxide solution was added. The methylene chloride layer was separated, dried over anhydrous potassium carbonate, filtered and the solvent removed under reduced pressure. To the residue was then added 60 ml of 1,2-dichloroethane and 1.00 g (10 mmol) of succinimide. After refluxing for twelve hours under a nitrogen atmosphere, the reaction mixture was cooled, washed twice with 100 ml of 5% sodium hydroxide solution, dried with magnesium sulfate, filtered and concentrated under reduced pressure to afford 24.9 g of a black oil. This was distilled under reduced pressure to afford 16.5 g (63% yield) of the desired product as a clear, colorless liquid (Bp 106-110 at 0.35 mm Hg) of 95% purity as assayed by gas chromatography; 1 H NMR analysis indicated: (delta, CDCl3) 6.94 (d, J=1.8 Hz, 1H), 6.78 (d, J=1.8 Hz, 1H), 4.32 (br s, 2H, NHz), 3.54 (s, 3H), 3.51 (s, 2H) and 1.82 (s, 3H). Mass spectrum analysis indicated: (m/e) 251 (M+), 204 (100%) and 181.

The synthetic route of 4-Methoxy-2-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 456-55-3, name is (Trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 456-55-3, Formula: C7H5F3O

EXAMPLE 1 4-Trifluoromethoxybenzaldehyde (A) with (2-trifluoromethoxybenzaldehyde (B)) 0.5 liter (25 Mol) of HF is added with brine cooling (5 C.) to 162 g (1 mol) of trifluoromethoxybenzene and 140 g (1 mol) of urotropine in a V4 A stainless steel stirred autoclave. The apparatus is sealed pressuretight and heated to 80 C. for 5 hours. A pressure of 6 to 7 bar becomes established. When the reaction has ended, the crude reaction mixture, which is cooled down to 25 C., is stirred into 1 liter of water and stirred therein at 5 C. for 15 minutes, the organic content is then isolated, and the aqueous phase is extracted with methylene chloride. Crude distillation of the washed organic phases gives 135 g of product (boiling point: 72-74 C./8 mbar).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 954235-78-0, A common heterocyclic compound, 954235-78-0, name is 4-Bromo-2-(difluoromethoxy)-1-fluorobenzene, molecular formula is C7H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-bromo-2-fluoro-1-difluoromethoxybenzene (1.0 g, 4.1 mmol),bis(pinacolato)diboron (1.3 g, 5.0 mmol), 1,1-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane complex (0.3 g, 0.4 mmol), KOAc (0.8 g, 8.3 mmol), and anhydrous 1,4-dioxane (8.3 mL) are added to a pressure vessel. Argon is bubbled through the solution for several minutes. The vessel is sealed and is heated at 85 C overnight. After cooling to RT, the reaction mixture is diluted with EtOAc and filtered through diatomaceous earth. The filtrate is concentrated to crude blackish oil under reduced pressure and is dissolved in acetone (14 mL). The resulting suspension is cooled to 0 C and a solution of potassium peroxymonosulfate (3.1 g, 5.0 mmol) in water (13.8 mL) is added over 10 min. After stirring for 2 h while maintaining the temperature at 0C, the reaction mixture is diluted with water (40 mL), and the mixture is extracted with EtOAc (3 x 40 mL). The resulting layers are separated, and the combined organic layers are washed with saturated aqueous NaCl, dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue is purified by silica gel flash column chromatography, using a gradient of 10-50% EtOAc in hexanes, to yield the title compound (0.77 g, quantitative yield) as a yellow oil. ES/MS m/z 176.8 [M-H].

The synthetic route of 954235-78-0 has been constantly updated, and we look forward to future research findings.

Application of 35202-55-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35202-55-2 as follows.

Step 2: ethyl (3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)carbamate 1.5 mL of ethyl chloroformate are poured into a suspension of 3.4 g of the compound obtained in Step 1 in 4.5 mL of triethylamine and 50 mL of dichloromethane and left overnight, whilst stiffing at ambient temperature; washing with water and with 1N hydrochloric acid is then carried out. Drying is carried out and the solvent is evaporated off to dryness. 3.2 g of an oil corresponding to the expected product are obtained. Yield=80%

According to the analysis of related databases, 35202-55-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15799-79-8 as follows. HPLC of Formula: C9H13NO

General procedure: (Scheme 1: cat.= H3PW12O40, oxidant= air, solvent= DMSO/CH3CO2H). A 50mL flask equipped with a magnetic stirrer was charged with 1,4-naphthoquinone (1) (20mmol; 3.16g), aromatic compounds (10mmol), 15mL of CH3COOH and H3PW12O40 (288mg; 1mol%). The flask was heated at 100C for 24h. After that time, the flask was cooled down to room temperature and 15mL of chloroform was added. The solution was washed with 20mL of brine. The organic phase was separated and dried by MgSO4. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel, using a gradient hexane/acetone mixture as eluent.

According to the analysis of related databases, 15799-79-8, the application of this compound in the production field has become more and more popular.

Application of 131713-50-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131713-50-3, name is 2,2-Dimethoxypropan-1-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The precursor 2,2-dimethoxypropylamine can be preparedaccording to the methodology described, for example, in Cui, P.et al., Bioorganic & Medicinal Chemistry Letters, 2006, 16(13),3401-3405. A previously prepared solution of 2,2- dimethoxypropylamine in anhydrous tetrahydrofuran (5.4 g of the amine (41.16 mmol) in 50 mL of the organic solvent) was slowlyadded at a temperature of -5C to the solution obtained according to the methodology described in Comparative Example 6. Once the addition ended, the temperature of the obtained mixture was increased to about 20C, and it was kept under stirring for 16 hours at a temperature of about 20C.Once it no longer had to be kept under the aforementioned conditions, 50 mL of an 8% aqueous NaHCO3 solution and 50 mL of 2-methyltetrahydrofuran were added. The resulting mixture was kept under stirring for about 5 minutes and the resulting organic phase containing (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e] [l,4]diazepin-3- yl]propionic acid methyl ester was subsequently separated. The organic solvent was vacuum-distilled, and 50 mL of acetone were added to the resulting residue. The obtained mixture was heated at the reflux temperature and then slowly cooled to about 20C.The resulting solid was filtered and oven-dried, finally obtaining 5.2 g (75.7% from 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2- yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester of formula (D), with a purity of 98.5% by means of UPLC) of (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin- 2-yl-3H-benzo[e] [1,4]diazepin-3-yl]propionic acid methyl ester.Figure 6 shows the 1H-NMR spectrum. 1H-NMR (CDC13, 400 MHz)6 (ppm) : 8.65 (1H, d) , 7.79 (2H, m) , 7.48 (1H, dd) , 7.35 (2H, m)7.10 (1H, d) , 5.18 (1H, m) , 3.70 (3H, s) , 3.64 (1H, dd) , 3.45(1H, dd), 3.31 (1H, dd), 3.22 (3H, s), 3.21 (3H, s), 2.77(1H,m) , 2.65-2.37 (3H, m) , 1.72 (1H, s) , 1.29 (3H, s)Figure 7 shows the 13C-NMR spectrum. 13C-NMR (CDC13, 400MHz) 6(ppm): 173.31, 167.89, 156.77, 154.75, 149.57, 149.16,136.57, 133.78, 133.07, 128.51, 127.10, 124.44, 124.24, 112.33,100.14, 60.24, 51.80, 48.65, 48.62, 45.72, 30.84, 26.23, 20.57.

The synthetic route of 2,2-Dimethoxypropan-1-amine has been constantly updated, and we look forward to future research findings.