In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 592-55-2 as follows. Quality Control of 1-Bromo-2-ethoxyethane
To a solution of 3-(3-ethylazepan-3-yl)phenol (step a, 0.42 g, 1.92 mmol) in ACN (20 mL), N-ethyldiisipropylamine (0.67 mL, 3.830 mmcl) and 1-bromo-2-ethoxyethane (0.24 mL, 2.11 mmol) were added and the reaction mixture was heated at 65?C overnight. The reaction mixture was cooled and partitioned between 5% aqueous KHCO3 solution and AcOEt. The layers were separated and the organic layer wasdried over anh Na2SO4, filtered and concentrated to dryness. The crude product thus obtained was purified by flash chromatography on silica gel, gradient DCM/MeOH (0 to 10% MeOH) to give the title compound (0.15 g, 28% yield).HPLC-MS (Method A): Ret, 2.12 min; ESI-MS m/z, 292.4 (M+H).
According to the analysis of related databases, 592-55-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; MERCE-VIDAL, Ramon; ALMANSA-ROSALES, Carmen; GARCIA-LOPEZ, Monica; (148 pag.)WO2017/121645; (2017); A1;,
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