Electric Literature of 36865-41-5,Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred mixture of 51d (1.00 g, 1 eq) in DMSO (8 mL), is added Cs2CO3 (3.51 g, 3 eq). After stirring for 5 min, 2-bromoethyl methylether (0.62 mL, 1.5 eq) is added and the solution is stirred at RT during 18 h. The reaction mixture is quenched with H2O, extracted with EtOAc (3×), the combined organic extracts are washed with H2O (3×), brine, dried over Na2SO4 and concentrated. The resulting residue is purified by flash chromatography Hex/EtOAc (1:1) to give 51e (1.20 g, 98%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-methoxypropane, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/261714; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem