Synthetic Route of 1462-37-9,Some common heterocyclic compound, 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 83-Amino-6-(2-benzyloxy-ethoxy)-indazole-1-carboxylic acid tert-butyl esterScheme 1, Step Hb)A mixture of 3-amino-6-hydroxy-indazole-1-carboxylic acid tert-butyl ester (249 mg, 1 mmol), K2CO3 (152 mg, 1.1 mmol) and benzyl 2-bromoethyl ether (0.179 ml, 1.1 mmol) in dry DMF (5 ml) was stirred at 50°C for 12h. More benzyl 2-bromoethyl ether (30 muIota) was added and the mixture stirred at 50°C for additional 4h. The reaction mixture was poured into water (50 ml) and extracted with EtOAc (50 ml). The organic layer wad dried over sodium sulfate and evaporated to dryness. The crude residue was purified by flash chromatography over silica gel eluting with DCM / EtOAc 7:3 affording 274 mg (yield: 72percent) of the title compound.1H-NMR (400 MHz), delta (ppm, DMSO-cie): 7.71 (d, J=8.66 Hz, 1 H), 7.48 (bs, 1 H), 7.38 – 7.27 (m, 5H), 6.91 (dd, J=2.19, 8.66 Hz, 1 H), 6.19 (bs, 2H), 4.59 (s, 2H), 4.25 – 4.20 (m, 2H), 3.85 – 3.80 (m, 2H), 1.58 (s, 9H) ESI (+) MS m/z 384 (MH+)
The synthetic route of 1462-37-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; LOMBARDI BORGIA, Andrea; CIOMEI, Marina; DONATI, Daniele; NESI, Marcella; WO2012/152763; (2012); A1;,
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