Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 136-90-3, name is 4-Methoxy-3-methylphenylamine, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11NO
To a solution of 4-methoxy-3-methyl aniline (8 g, 58.39 mmol) in THF (100 mL), maintained at 0C, was added pyridine (5.8 mL, 72.98 mmol), followed by phenyl chloroformate (7.2 mL, 58.39 mmol). The reaction mixture was stirred at r.t. for 2 h, then quenched with water (50 mL) and extracted with EtOAc (2 x 100 mL). The organic layer was separated and washed with water (50 mL), then dried over sodium sulfate and concentrated in vacuo, to afford the title compound (13 g, 86%). deltaEta (CDC13, 400 MHz) 7.45-7.34 (m, 2H), 7.34-7.13 (m, 5H), 6.84 (s, 1H), 3.81 (s, 3H), 2.21 (s, 3H).
The synthetic route of 136-90-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HORSLEY Helen Tracey; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193169; A1; (2015);,
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