Synthetic Route of 24988-36-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24988-36-1, name is 1,5-Dibromo-2,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Add to the dry three-necked flask with a magnetic rotor 1,3-dibromo-4,6-dimethoxybenzene (2.5000 g, 8.53 mmol, 1.0 eq.),4-tert-butylbenzeneboronic acid (3.1890 g, 17.92 mmol, 2.1 eq.),tetrakistriphenylphosphine palladium (0.9820 g, 0.85 mmol, 0.1 equivalent) and potassium carbonate (4.7160 g, 34.1 mmol, 4.0 eq.).Nitrogen gas was purged three times, then 1,4-dioxane (30 mL) and water (10 mL) were added under nitrogen.The three vials were then placed in a 110 C oil bath.After stirring for 48 hours, the reaction was monitored by thin layer chromatography. After cooling to room temperature, the organic phase was separated and aqueous was extracted with ethyl acetate (30mL×2). All the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated, and then the crude product was purified by silica gel column chromatography (eluent: petroleum ether / ethyl acetate = 20/1-10/1) to obtain A3 , white solid 3.4040 g, yield 99%.
The synthetic route of 1,5-Dibromo-2,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Li Guijie; Dai Jianxin; Chen Shaohai; Feng Qi; (28 pag.)CN110183476; (2019); A;,
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