Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, A new synthetic method of this compound is introduced below., Quality Control of (4-(Trifluoromethoxy)phenyl)methanamine
General procedure: To a solution of 2-(dibenzo[b,d]thiophen-2-yl)imidazo[1,2-a]pyridine-3-carboxylic acid 5 (2.83mmol) in anhydrous DMF (10mL) were added 1-[3-(dimethyl amino)propyl]-3-ethylcarbodiimide (EDCI, 3.84mmol), 1-hydroxybenzo triazole (HOBt, 1.54mmol), triethyl amine (TEA, 5.12mmol) and 6a-s (2.56mmol) at room temperature, and the resulting solution was heated at 80C with stirring. After 12h, the reaction mixture was cooled to room temperature and evaporated. Water (50mL) was added into the crude residue, the resulting solid was collected by filtration, and the filtered cake was washed with water (50mL) and dried to afford crude product. The resulting crude compound was purified by column chromatography over silica gel (n-hexane/EtOAc=1:1) to give 7a-s as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Pulipati, Lokesh; Sridevi, Jonnalagadda Padma; Yogeeswari, Perumal; Sriram, Dharmarajan; Kantevari, Srinivas; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 3135 – 3140;,
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