Related Products of 1484-26-0,Some common heterocyclic compound, 1484-26-0, name is 3-Benzyloxyaniline, molecular formula is C13H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Specifically, a solution of 3-benzyloxyaniline 2e (0.84 g, 4.2 mmol) and diphenylcyanocarbonimidate 1 (1.0 g, 4.2 mmol) in 2-PrOH (15 ml_) was stirred at ambient temperature under N2. After 5 h, the solids were collected by filtration washing with cold 2-PrOH to afford 3e (1.25g, 86percent) as a white solid: 1H NMR (300 MHz, DMSO- d6) delta 7.47-7.26 (m, 12H), 7.17 (s, 1H), 7.05 (d, J = 7.9 Hz, 1H), 6.90 (d, J = 8.3 Hz, 1H), 5.10 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Benzyloxyaniline, its application will become more common.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2007/30680; (2007); A2;,
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