Synthetic Route of 592-55-2, These common heterocyclic compound, 592-55-2, name is 1-Bromo-2-ethoxyethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 250 mL flask, 2-bromoethyl ether (37.62 g, 0.246 mol),4-hydroxybenzaldehyde (32 g, 0.262 mol), anhydrous potassiumcarbonate (67.89 g, 0.491 mol) and 120 mL acetonitrilewere added. The solution was heated to reflux for 24 h.Then, the solvent was evaporated in vacuo and the residuewas dissolved in H2Oand extracted with ethyl acetate. Theorganic layers were washed with 2× 100 mL sodium hydroxidesolution (1 N) and with 2× 100 mL saturated brine,respectively. The obtained solution was concentrated to getthe pure product, yield 81%. 1H NMR (400 MHz, CDCl3)delta 9.72 (s, 1H, CHO), 7.68 (m, 2H, benzyl), 6.89 (m, 2H,benzyl), 4.05 (t, 2H, OCH2CH2O), 3.67 (t, 2H, OCH2CH2O),3.45 (q, 2H, -CH2CH3), 1.09 (t, 3H, CH3). Mass (ESI): calcdfor C11H14O3(M + H)+, 195.27; found 195.52.
Statistics shows that 1-Bromo-2-ethoxyethane is playing an increasingly important role. we look forward to future research findings about 592-55-2.
Reference:
Article; Wu, Fengshou; Yang, Mengqian; Zhang, Juan; Zhu, Sizhe; Shi, Mengge; Wang, Kai; Journal of Biological Inorganic Chemistry; vol. 24; 1; (2019); p. 53 – 60;,
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