Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Methoxyphenyl)ethylamine
To a solution of [3-(3,5-Dimethoxy-phenyl)-1 ,4-dimethyl-1 H-pyrazolo[3,4-b]pyridin-6-yloxy]- acetic acid (building block A1 , 100 mg, 0.28 mmol) in CH2CI2 were added HOBt x H20 (64 mg, 0.42 mmol), EDC x HCI (80 mg, 0.42 mmol) and NEt3 (0.12 ml, 0.84 mmol). After stirring at rt for 5 min, (S)-1-(4-methoxyphenyl)ethanamine (64 mg, 0.42 mmol) was added andstirring continued for 18 h. Then, water was added and the mixture extracted 3 times withDCM. The organic phases were dried over Na2S04 and the solvent removed under reduced pressure. Purification by reverse phase HPLC (Sunfire C18 OBD column) followed byliberation of the free base (SPE cartridge SCX-1 , eluent 7M NH3 in methanol) yielded the title compound (17 mg, 12%). [1 H-NMR (DMSO-d6, 600 MHz) delta 8.48 (d, 1 H), 7.21 (d, 2H),6.82 (d, 2H), 6.70 (s, 1 H), 6.58 (s, 1 H), 5.00-4.88 (m, 1 H), 4.87 (d, 1 H), 4.83 (d, 1 H), 3.85 (s, 3H), 3.78 (s, 6H), 3.70 (s, 3H), 2.37 (s, 3H), 1.37 (d, 3H); UPLC-MS Rtj = 1.14 min; [M+H]+ = 491.2]
According to the analysis of related databases, 6298-96-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; BADIGER, Sangamesch; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; CHEBROLU, Murali; COSTESTA, Simona; HINTERMANN, Samuel; MEYER, Arndt; PANDIT, Chetan; WO2011/76744; (2011); A1;,
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