Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1535-75-7, name is 2-(Trifluoromethoxy)aniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Trifluoromethoxy)aniline
Add in a 25 ml two-neck round bottom flask2-methylaniline(53.5 mg, 0.5 mmol), Pd2(dba)3 (0.05 g, 10 mol%), NaHCO3 (12.5 mg, 30 mol%), pivalic acid 0.44 g and stirring magnet, after replacing oxygenN,N-dimethylacetamide 2 ml and methyl trifluoromethyl propyrate (91.2 mg, 0.6 mmol) were added. Stir at 120CAfter 12h, TLC was followed by a complete reaction and column chromatography gave a white solid, ie 7-methyl-2-trifluoromethyl-1H-indole-3-carboxylic acid.Methyl esters.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Maikelin Biochemical Technology Co., Ltd.; Shen Dandan; Han Jing; Chen Jie; Zhang Hui; Cao Weiguo; (23 pag.)CN104892485; (2018); B;,
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