Synthetic Route of 171290-52-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A mixture of 2 (0.50 g, 1.40 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.05 g, 0.07 mmol), copper(I) iodide (0.03 g,0.14 mmol), triphenylphosphine (0.02 g, 0.08 mmol) and triethylamine(0.17 g, 1.68 mmol) in 4:1 DMF-water (v/v, 20 mL) was placed in a two necked round-bottomed flask equipped with a stirrer bar, condenser and a rubber septum. The mixture was flushed with argon gas for30 min and a solution of phenylacetylene derivative (1.2 equiv.) in DMF(2 mL) was introduced via a rubber septum by means of a syringe. A balloon filled with argon was connected to the top of the condenser andthe mixture was left to stir at 70 C for 2 h. The mixture was allowed to cool and then poured into crushed ice. The product was extracted into chloroform and the combined organic phases were washed with water and dried over anhydrous MgSO4. The salt was filtered off and the solvent was evaporated under reduced pressure on a rotary evaporator.The residue was purified by column chromatography on using silica gelusing 9:1 toluene-ethyl acetate mixture (v/v) as an eluent. The following compounds were prepared in this fashion.
The chemical industry reduces the impact on the environment during synthesis 3,5-Dimethoxyphenylacetylene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Olomola, Temitope O.; Mphahlele, Malose J.; Journal of Fluorine Chemistry; vol. 229; (2020);,
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