6781-17-5, name is 2-(2-Ethoxyphenoxy)ethanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C10H15NO2
Example 13 (2-Benzenesulfonyl-ethyl)-[2-(2-ethoxy-phenoxy)-ethyl]-amine hydrochloride A mixture of 2-(2-ethoxyphenoxy)ethanamine (36.2 g, 200 mmol) and [(2-phenoxyethyl)sulfonyl]-benzene (52.5 g, 200 mmol) in 500 mL of tetrahydrofuran is treated in portions with 50% sodium hydride in mineral oil suspension (9.7 g, 202 mmol). The mixture is stirred at room temperature for 1 hour and then evaporated. The residue is partitioned between ethyl ether and brine. The ether layer is dried (anhydrous magnesium sulfate) and treated with hydrogen chloride gas. The precipitated solid is filtered and recrystallized from ethanol to give 49.6 g (64%) of product, mp 146-152 C.
The synthetic route of 6781-17-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Warner-Lambert Company; US6051605; (2000); A;,
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