Application of 801282-00-8, The chemical industry reduces the impact on the environment during synthesis 801282-00-8, name is 2-Fluoro-3-methoxyaniline, I believe this compound will play a more active role in future production and life.
2,2-dimethyl-l ,3-dioxane-4,6,-dione (4.58 g, 31.78mmol) in trimethyl orthoformate (27.3mL, 245.9 mmol) was refiuxed at 100 C for 1 hr. 2-fluoro-3-methoxyaniline (3.9 g, 27.63 mmol) was then added and refluxing was continued for an additional hour. The reaction was cooled to room temperature and the suspension was filtered. The solid was washed with MeOH (60 mL) and dried under vacuum to yield the title compound. XH NMR H20438-004-04 (400MHz, chloroform-d) delta= 1 1.36 – 1 1.38 (m, 1H), 8.63-8.60 (m, 1H), 7.26- 6.83 (m, 3H), 3.92 (s, 3H), 1.75 (s, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-3-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CALDWELL, John, P.; CAPLEN, Mary Ann; CUMMING, Jared, N.; DYKSTRA, Kevin, D.; HRUZA, Alan; LANKIN, Claire; LI, Derun; LIU, Hong; MCCRACKEN, Amy; MCKITTRICK, Brian; RAO, Ashwin; TAGAT, Jayaram, R.; TANG, Haiqun; TAOKA, Brandon, M.; VERRAS, Andreas; WALSH, Shawn, P.; WU, Wen-Lian; ZHANG, Tianyuan; (132 pag.)WO2018/34917; (2018); A1;,
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