Synthetic Route of 36805-97-7, These common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation GW-(2,6-diethylphenyl)-5-[(2E)-3-(dimethyta [(VI) R2 =Me, R3 = CONHR”, R” = 2,6-diethylphenyl]step 5To a solution of 5-acetyl-/V-(2,6-diethylphenyl)-1-methyl-1 H-pyrazole-3-carboxamide (0.013 g, 0.043 mmol) in DMF (1.5 mL), A/,A/-dimethylformamide di-tertbutyl acetal (0.0.63 mL, 0.650 mmol) was added. The mixture was stirred at 80C for 2 h. The reaction was diluted with water, extracted with AcOEt (2×20 mL). The organic fractions were combined, dried over Na2S04, filtered, and concentrated in vacuo and the residue used without any further purification. (0.017g, 78% yield).1H NMR (400 MHz, DMSO-d6) delta ppm 9.58 (s, 1 H), 7.71 (d, J =12.33 Hz, 1 H), 7.36 (s, 1 H), 7.21 (t, J =7.60 Hz, 1 H), 7.12 (d, J =7.60 Hz, 2 H), 5.75 (d, J =12.33 Hz, 1 H), 4.18 (s, 3 H), 3.16 (s, 3 H), 2.92 (s, 3 H), 2.52 (q, J =7.57 Hz, 4 H), 1.09 (t, J =7.57 Hz, 6 H)HRMS (ESI) calcd for C20H27N4O2 [M +H]+ 355.2129, found 355.2133.
The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; CASUSCELLI, Francesco; BRASCA, Maria Gabriella; CALDARELLI, Marina; CERVI, Giovanni; DISINGRINI, Teresa; QUARTIERI, Francesca; WO2012/139930; (2012); A1;,
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