Related Products of 4393-09-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of (2,3-dimethoxyphenyl)methanamine (SM-2) (5 g, 29.9 mmol) in THF (50 mL) were added Et3N (8.3 mL, 59.8 mmol) dropwise at 0 C. After stirring for 15 minutes, 2- bromoacetonitrile (2.5 mL, 35.9 mmol) dropwise at 0 C. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was stirred at room temperature for 16 h.After consumption of the starting material (by TLC), the reaction was quenched with water (100 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layer was washed with brine, dried over Na2S04and concentrated under reduced pressure. The crude was purified by column chromatography by eluting 20% EtOAc/n-hexane to afford Int-A (5 g, 82%) as colorless thick syrup.1H NMR (400 MHz, DMSO -d6) delta 7.07 – 7.00 (m, 1H), 6.98 – 6.89 (m, 2H), 3.79 (s, 3H), 3.76 – 3.74 (m, 2H), 3.73 (s, 3H), 3.59 (br d, J = 5.9 Hz, 2H), 2.81 (br s, 1H)
The synthetic route of (2,3-Dimethoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; APTINYX INC.; KHAN, M., Amin; (87 pag.)WO2019/152685; (2019); A1;,
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