Electric Literature of 2338-54-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2338-54-7, name is 4-Fluoro-3-methylanisole, This compound has unique chemical properties. The synthetic route is as follows.
To a 250 mL three-necked flask was added 1-fluoro-4-methoxy-2-methylbenzene (18.3 g, 130.6 mmol)Under ice-cooling, sulfonyl chloride (27.4 g, 235.0 mmol) was slowly added dropwise and reacted at room temperature for 2 h. After completion of the reaction, the reaction solution was poured into ice water and analyzed.A large amount of solid was added, and the filter cake was dried in vacuo to give 23.2 g of 5-fluoro-2-methoxy-4-toluenesulfonyl chloride in 74.5% yield.
The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-3-methylanisole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Guizhou University; Liu Li; Quan Wen; Zhang Menghui; Huang Zhuyan; (6 pag.)CN106674065; (2017); A;,
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