Application of 5307-02-8, These common heterocyclic compound, 5307-02-8, name is 2-Methoxybenzene-1,4-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2.00 g (1 1.9 mmol) 2-chloro-l,3-dimethyl-4,5-dihydro-lH-imidazoL3-ium chloride (II) in 20 mL acetonitrile were added to a suspension of 0.66 g (4.7 mmol) 2-methoxybenzene-l ,4- diamine in 20 mL acetonitrile and 2.4 mL triethylamine under argon atmosphere. The mixture was stirred for 50 hours at room temperature. After filtration of the precipitate and distillation of the solvent, the residue was suspended in 2 M aqueous sodium hydroxide solution and stirred for 5 minutes at 45 C. The precipitate was filtered, the solvent distilled off, the residue suspended in acetonitrile/methanol mixture and filtered through an alumina pad (Polygram Alox N/UV254). 1.2 g (3.63 mmol; 77 %) orange solid were obtained after drying in vacuo. The product was purified by gradient sublimation for analytical characterisation. (0097) Melting point: 149 C
The synthetic route of 5307-02-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVALED GMBH; DOROK, Sascha; (34 pag.)WO2016/1425; (2016); A2;,
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