Synthetic Route of 3469-08-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-08-7, name is 6-Methoxy-1H-indene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 4 (1.00 g; 6.84 mmol; 1.00 eq.) in 50 ml of 3:1 tetrahydrofuran (37.50 ml) water (12.50 ml) and 1,3-dibromo-5,5-dimethylhydantoin (0.98 g; 3.42 mmol; 0.50 eq.) was stirred at room temperature for 30 min. Most of the THF was removed by rotaevaporation, and the product was extracted into ethyl acetate. The ethyl acetate layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to yield a brown oil, which was dissolved in diethyl ether but no precipitation formed:The crude product was purified by Sepacore chromatography with DCM as eluent. 850 mg of 5 were obtained as a white solid.
The synthetic route of 6-Methoxy-1H-indene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Abbott Laboratories; Abbott GmbH & Co. KG; US2012/40948; (2012); A1;,
Ether – Wikipedia,
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