Synthetic Route of 126940-10-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of compound 2 (25 g, 130.2mmol, 1 .Oeq) in dry THF (250ml_) and dry cyclohexane (40ml_) was added sec-BuLi (121.82ml_, 195.3mmol, 1.5eq) drop wise at -78 C under argon. The mixture was stirred for 2h at the same temperature, then compound 3 (62ml_, 520.3mmol, 4. Oeq) was added with sitrring for 10mins at the same temperature. TLC analysis indicated formation of a polar spot then the reaction mass was quenched with satd. NH4CI solution; the reaction mixture was dissolved in ether (2X500mL) and washed with brine (2 x 200mL) & water (2x200mL). The separated organic layer was dried over Na2S04 and concentrated under reduced pressure to give a crude product; which was purified by column chromatography (silica gel 100- 200mesh) using 1 % EtOAc petroleum ether as an eluent to give compound 4 ( 20g, 45.1 % ) as a pale yellow color liquid.
The chemical industry reduces the impact on the environment during synthesis 1-Fluoro-3-(methoxymethoxy)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem